| 李从圣,王勇,朱毅,等.可溶性基质裂解素2与慢性心力衰竭病人心功能相关性[J].安徽医药,2019,23(4):654-656. |
| 可溶性基质裂解素2与慢性心力衰竭病人心功能相关性 |
| Study on correlation between sST2 and cardiac function in patient with chronic heart failure |
| 投稿时间：2017-07-03 |
| DOI： |
| 中文关键词: 心力衰竭 超声检查,多普勒,彩色 可溶性血清基质裂解素 因果律 |
| 英文关键词: Heart failure Ultrasonography,dopple,color Soluble serum matrix lysin Causality |
| 基金项目:安徽省合肥市2016年度科技攻关计划资助项目(合科〔2017〕3号) ◇心血管疾病◇可溶性基质裂解素2与慢性心力衰竭病人心功能相关性李从圣,王勇,朱毅,张尧,聂开政,宋瑞,杨静 (安徽医科大学第三附属医院(合肥市第一人民医院)急诊部,安徽 合肥 230061) |
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| 中文摘要: |
| 目的 观察慢性心力衰竭(CHF)病人血清可溶性基质裂解素2(sST2)的水平变化,探讨其与心功能的关系。方法 入选2016年1月至2017年6月合肥市第一人民医院CHF住院病人76例,采用心脏彩色多普勒超声测量左室射血分数(LVEF)、左室舒张末内径(LVEDD),采用酶联免疫吸附法检测血清sST2水平；根据纽约心脏病学会(NYHA)心功能分级、LVEF、LVEDD进行分组,各组之间进行sST2水平比较。结果 CHF病人血清sST2水平在心功能Ⅱ[(0.47±0.32)ng/mL]、Ⅲ[(0.85±0.43) ng/mL]、Ⅳ[(1.41±0.57) ng/mL]级间差异有统计学意义,且随着心功能分级的升高而逐渐增高(均P＜0.05)；射血分数下降组血清sST2水平显著高于射血分数中间值组和射血分数保留组(均P＜0.05),射血分数中间值组显著高于射血分数保留组(P<0.05)；随着病人LVEDD增大,sST2水平显著升高(均P<0.05)；sST2水平与LVEF呈负相关(r=-0.461,P<0.05),sST2与LVEDD呈正相关(r=0.436,P<0.05)。结论 sST2水平与CHF心功能状态有关,sST2水平可作为评估CHF严重程度的重要指标。 |
| 英文摘要: |
| Objective To observe the levels of serum soluble ST2 (sST2) in patient with chronic heart failure (CHF),and to investigate the correlation between sST2 and cardiac function.Methods Seventy-six patients with CHF hospitalized in the Department of Emergency,The First People's Hospital of Hefei from January 2016 and June 2017 were selected.Left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD) were measured by cardiac color Doppler ultrasonography.Serum sST2 levels were determined by enzyme-linked immunosorbent assays.ResultsSerum sST2 levels among different heart function Ⅱ[(0.47±0.32)ng/mL],Ⅲ[(0.85±0.43) ng/mL],Ⅳ[(1.41±0.57) ng/mL] showed significantly different,and increased gradually along with the rise of heart function in patient with CHF (P<0.05 for all). Patients with reduced ejection fraction (HFrEF) had significantly higher levels of sST2 than mid-range ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) (P<0.05 for all),HFmrEF higher the HFpEF (P<0.05).Additionally,the higher of serum sST2 levels,the increase of LVEDD in patient with CHF (P<0.05 for all).The serum sST2 levels were negatively correlated with LVEF (r=-0.461,P <0.05),but positively correlated with LVEDD (r=0.436,P<0.05).Conclusion Serum sST2 levels are closely related to cardiac function in patient with CHF,so it may be an important parameter reflecting the severity of CHF. |
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