| 库尔班江·吐尔逊,买买提吐尔洪·吐尔逊.慢性心力衰竭病人血清高密度脂蛋白胆固醇、 高敏肌钙蛋白T水平与心功能指标的相关性[J].安徽医药,2019,23(4):713-716. |
| 慢性心力衰竭病人血清高密度脂蛋白胆固醇、 高敏肌钙蛋白T水平与心功能指标的相关性 |
| Relationship between high-density lipoprotein,high-sensitivity cardiac troponin Tand cardiac function in patients with chronic heart failure |
| 投稿时间：2017-08-03 |
| DOI： |
| 中文关键词: 心力衰竭 胆固醇,HDL 肌钙蛋白T 心脏功能试验 因果律 |
| 英文关键词: Heart failure Cholesterol,HDL Troponin T Heart function tests Causality |
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| 中文摘要: |
| 目的 分析血清高密度脂蛋白胆固醇(HDL-C)、高敏肌钙蛋白T(Hs-cTnT)水平在慢性心力衰竭发生、发展中的价值。方法 选取2013年2月至2016年6月新疆维吾尔自治区人民医院收治的慢性心力衰竭住院病人(慢性心衰组,n=200)以及健康体检者(健康对照组,n=86)为研究对象,并根据美国心脏病协会(NYHA)心功能分级将慢性心衰组进一步分为Ⅱ级(n=43)、Ⅲ级(n=111)、Ⅳ级(n=46) 3个亚组。比较四组受试者间血清HDL-C、Hs-cTnT水平,所有受试对象均行超声心动图检查,测定左室射血分数(LVEF),采用Spearman等级相关分析慢性心力衰竭病人心功能分级、LVEF与血清HDL-C、Hs-cTnT水平的相关性。结果 慢性心衰组病人血清HDL-C(0.98±0.64)mmol/L低于健康对照组(1.59±0.58)mmol/L(t=7.256,P<0.001),血清Hs-cTnT(0.34±0.12)ng/mL高于健康对照组(0.04±0.02)ng/mL(t=8.978,P<0.001)。慢性心衰组病人血清HDL-C水平、LVEF由低到高依次为Ⅳ级、Ⅲ级、Ⅱ级；而血清Hs-cTnT水平由高到低依次为Ⅳ级、Ⅲ级、Ⅱ级。不同心功能分级病人血清HDL-C、Hs-cTnT水平以及LVEF均差异有统计学意义(F=33.451,P=0.000；F=37.302,P=0.000；F=53.701,P=0.000)。Spearman相关分析结果显示,慢性心衰组病人血清HDL-C水平与心功能分级呈负相关(rs=-0.483,P=0.000),与LVEF呈正相关(rs=0.221,P=0.002)；血清Hs-cTnT水平与心功能分级呈正相关(rs=0.693,P=0.000),与LVEF呈负相关(rs=-0.433,P=0.000)；慢性心衰组病人血清HDL-C水平与血清Hs-cTnT水平呈负相关(rs=-0.284,P=0.000)。结论 慢性心力衰竭病人HDL-C水平降低、Hs-cTnT水平增高,且其血清水平与病人心功能状态显著相关,测定血清HDL、Hs-cTnT水平有利于慢性心力衰竭疾病的预防、治疗及预后评估。 |
| 英文摘要: |
| Objective To analyze the value of high-density lipoprotein cholesterol (HDL-C) and high-sensitivity cardiac troponin T (Hs-cTnT) in the development and progression of cardiac function.Methods Two hundred cases of patients with chronic heart failure admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from February 2013 to June 2016 were selected as chronic heart failure group,and assigned into three subgroup of grade Ⅱ (43 cases),grade Ⅲ (111 cases),and grade Ⅳ (46 cases),according to the American Heart Association (NYHA) cardiac function classification;86 cases physical examination were selected as healthy control group.The serum levels of HDL-C,Hs-cTnT between chronic heart failure group,healthy control group and subgroup were compared.All patients underwent echocardiography,the left ventricular ejection fraction (LVEF) were measured.The relationship between cardiac function classification,LVEF and levels of serum HDL-C,Hs-cTnT were analyzed by Spearman linear correlation.Results The serum HDL-C level (0.98±0.64) mmol/L in patients with chronic heart failure was lower than (1.59±0.58) mmol/L of healthy controls (t=7.256,P=0.001).The serum Hs-cTnT (0.34±0.12) ng/mL in chronic heart failure group was higher than (0.04+0.02) ng/mL of healthy control group (t=8.978,P=0.001).The level of serum HDL-C and LVEF in patients with chronic heart failure were the lowest in grade Ⅳ of cardiac function,followed by grade Ⅲ of cardiac function and the highest in grade Ⅱ of cardiac function.The level of serum Hs-cTnT was the highest in grade Ⅳ of cardiac function,followed by grade Ⅲ of cardiac function and the lowest in grade Ⅱ of cardiac function.There were significant differences in serum HDL-C,Hs-cTnT levels and LVEF levels between different heart function classification subgroups in chronic heart failure group (F=33.451,P=0.000;F=37.302, P=0.000;F=53.701,P=0.000).Spearman correlation analysis showed that serum HDL-C level was negatively correlated with cardiac function classification (rs=-0.483,P=0.000) and positively correlated with LVEF (rs=0.221,P=0.002).Serum Hs-cTnT level was positively correlated with cardiac function grading (rs=0.693,P=0.000) and negatively correlated with LVEF (rs=-0.433,P=0.000).Serum HDL-C level was negatively correlated with serum Hs-cTnT level in patients with chronic heart failure (rs=-0.284,P=0.000).ConclusionsThe serum level of HD.L-C is decrease and Hs-cTnT is increase in patients with chronic heart failure,and HDL-C and Hs-cTnT level were correlated with cardiac function status.The detection of HDL-C and Hs-cTnT has important clinical significance in monitoring and controlling for the occurrence and development of chronic heart failure. |
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