| 谢斌,韦文萍,刘勇,等.高能聚焦超声刀联合单药吉西他滨化疗治疗局部晚期胰腺癌的临床观察[J].安徽医药,2019,23(4):792-794. |
| 高能聚焦超声刀联合单药吉西他滨化疗治疗局部晚期胰腺癌的临床观察 |
| Clinical observation on local advanced pancreatic carcinoma with high intensity focused ultrasound followed by chemotherapy with single-agent gemcitabine |
| 投稿时间：2018-01-10 |
| DOI： |
| 中文关键词: 胰腺肿瘤 高强聚焦超声消融 吉西他滨 化学疗法,辅助 治疗结果 |
| 英文关键词: Pancreatic neoplasms High-intensity focused ultrasound ablation Gemcitabine Chemotherapy,adjuvant Treatment outcome |
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| 中文摘要: |
| 目的 探讨高强度聚焦超声联合单药吉西他滨化疗治疗局部晚期胰腺癌的临床效果及不良反应。方法 将2010年6月至2017年6月六安市人民医院收治的42例局部晚期胰腺癌病人依据治疗措施的不同分为两组,对照组(19例)用单药吉西他滨化疗,吉西他滨1 000 mg/m2静脉滴注。观察组(23例)用单药吉西他滨化疗的同时加高能聚焦超声刀治疗。结果 (1)对照组治疗前功能状态评分(KPS评分)均值为(74.74±9.05)分,治疗后KPS评分均值为(76.32±8.95)分,组内差异无统计学意义(t=1.000,P=0.331)；观察组治疗前KPS评分均值为(72.61±10.10)分,治疗后KPS评分均值为(83.48±7.75)分,组内差异有统计学意义(t=4.800,P=0.000),两组组间比较差异有统计学意义(t=2.896,P=0.006)。(2)对照组治疗后的总缓解率为43.75%,观察组为83.33%,组间差异有统计学意义(P=0.030)。(3)对照组治疗后的临床受益率为26.32%,观察组为65.22%,差异有统计学意义(χ2=6.313,P=0.012)。(4)两组不良反应均为Ⅰ~Ⅱ级骨髓抑制,差异无统计学意义(P>0.05)。结论 高能聚焦超声刀联合单药吉西他滨化疗是治疗局部晚期胰腺癌的安全有效方法。 |
| 英文摘要: |
| Objective To evaluate the clinical effects and the adverse reactions of treatment with high intensity focused ultrasound followed by chemotherapy with single-agent gemcitabine in local advanced pancreatic carcinoma.Methods Forty-two cases of local advanced pancreatic carcinoma admitted to Lu'an People's Hospital from June 2010 to June 2017 were randomly assigned into two groups.The control group (19 cases) received chemotherapy with single-agent gemcitabine (1 000 mg/m2,i.v.gtt.) while the observation group received high intensity focused ultrasound followed by chemotherapy with single-agent gemcitabine.Results (1) In the control group,the average functional status score (KPS score) before the therapy and after the therapy was (74.74±9.05) and (76.32±8.95),respectively,and the difference in the group was statistically significant (t=1.000,P=0.331).In the observation group,the average KPS score before the therapy and after the therapy was (72.61±10.10) and (83.48±7.75),respectively,and the difference in the group was statistically significant (t=4.800,P=0.000).The difference of the average KPS score between the two groups is statistically significant (t=2.896,P=0.006).(2) The overall remission rate in the control group and in the observation group was 43.75% and 83.33%,respectively.The overall remission rate had significant different between the two groups (P=0.030).(3) The clinical benefit rate in the control group and in the observation group was 26.32% and 65.22%,respectively.The clinical benefit rate had significant different between the two groups (χ2=6.313,P=0.012).(4) The adverse reactions in both groups wereⅠto Ⅱ bone marrow suppression,and the difference was not statistically significant (P<0.05).Conclusion Patients with local advanced pancreatic carcinoma can be treated by high intensity focused ultrasound followed by chemotherapy with single-agent gemcitabine,which was an effective and safe method. |
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