| 何彩玲,高苏俊.白细胞吸附疗法在重症炎症性肠病中的应用进展[J].安徽医药,2019,23(4):827-830. |
| 白细胞吸附疗法在重症炎症性肠病中的应用进展 |
| Application of leukocyte adsorption therapy in severe inflammatory bowel disease |
| 投稿时间：2017-07-18 |
| DOI： |
| 中文关键词: 免疫吸附技术 结肠炎,溃疡性 Crohn病 单核细胞 中性白细胞 白细胞吸附疗法 炎症性肠病 |
| 英文关键词: Immunosorbent techniques Colitis,ulcerative Crohn disease Monocytes Neutrophils Leukocyte adsorption therapy Inflammatory bowel disease |
| 基金项目: |
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| 摘要点击次数: 1712 |
| 全文下载次数: 559 |
| 中文摘要: |
| 炎症性肠病(IBD)是一种以反复发作的、多种免疫因子参与的慢性肠道炎症,其发病率在逐年增加。其发病机制可能与机体免疫反应、肠道炎性活动、肠道功能紊乱、精神状态、遗传等因素有关。目前主要的治疗方式以营养疗法、药物治疗、单克隆抗体相关的生物治疗、免疫抑制剂疗法为主,因发病机制仍不十分明确,这些疗法都不能完全有效地控制炎症的发展。近年来研究发现,血液中的白细胞(中性白细胞和单核细胞)的激活在IBD的发生与发展中起着至关重要的作用,因此,有效地清除血液中激活的白细胞,中断炎症反应链,可以达到控制疾病进展的目的。许多研究者将白细胞免疫吸附疗法应用于对重症炎症性肠病(SIBD)病人的治疗,并取得了一定的效果。这是对目前IBD治疗的补充,也是一种研究思路,但其吸附效果、疗效、不良反应等还有待进一步研究。 |
| 英文摘要: |
| Inflammatory bowel disease (IBD) is a chronic colon inflammation which attacks recurrently with the involvement of many immune factors.The number of patients with these diseases is increasing by years,and the pathogenesis is likely to be related to the body's immune response,activation of colonic inflammation,intestinal dysfunction,mental state and inherent cause.The main therapies are nutritional therapy,drugs,biotherapy related to monoclonal antibody and immunosorbent therapy.Since the pathogenesis is still not clear,all of these methods cannot inhibit the inflammation progressing completely.According to recent studies,activation of white cells in serum,especially neutrophils and monocytes,has an essential effect in the progressing of IBD.Therefore,effective clearance of the activated white cells and cutoff of the reflection chain of inflammation can contribute to inhibiting the progressing of the disease.Many researchers have applied the leukocyte adsorption therapy to severe inflammatory bowel disease and achieved certain effects.Leukocyte adsorption therapy is a supplement to current therapies of IBD and also a research track,whose adsorption effect,efficacy and adverse reactions are to be further studied. |
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