| 张春霞.2型糖尿病病人同型半胱氨酸水平与靶器官功能损伤的
关联性研究[J].安徽医药,2019,23(5):932-935. |
| 2型糖尿病病人同型半胱氨酸水平与靶器官功能损伤的
关联性研究 |
| Association of homocysteine levels with targeted organs dysfunction in patients with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2019.05.025 |
| 中文关键词: 糖尿病,2型 半胱氨酸 颈动脉内膜中膜厚度 肾小球滤过率 蛋白尿 危险因素 |
| 英文关键词: Diabetes mellitus,type 2 Cysteine Carotid intima-media thickness Glomerular filtration rate Proteinuria Risk factors |
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| 中文摘要: |
| 目的 探讨2型糖尿病病人同型半胱氨酸(homocysteine,Hcy)水平与肾、心血管功能损伤的关联性。方法 自2014年1月至2016年1月,收集周口市人民医院收治的2型糖尿病120例,根据病人血液中同型半胱氨酸水平将病人分为研究组(Hcy≥10 μmol/L)和对照组(Hcy＜10 μmol/L)。观察两组病人颈动脉内膜中膜厚度(carotid intima-media thickness,cIMT)、动脉硬化指数、冠心病指数、肾小球滤过率、空腹血糖、胰岛素抵抗指数(HOMA-IR)和胰岛素功能指数(HOMA-β)。结果 与对照组比较,研究组HOMA-IR水平显著升高［(7.48±2.52)比(6.81±2.53),P＝0.000］;HOMA-β水平显著降低［(67.83±9.29)比(78.62±11.53),P＝0.000］。两组空腹血糖水平差异无统计学意义［(11.81±5.48) mmol/L比(11.40±5.93)mmol/L,P＝0.7530］。与对照组比较,研究组cIMT水平显著增高［(1.31±0.21) mm比(1.12±0.18) mm,P＝0.000］;动脉硬化指数显著增高［(3.93±2.21)比(2.74±1.83),P＝0.000］;冠心病指数显著升高［(2.39±0.65)比(1.92±0.58),P＝0.002］;肾小球率过滤显著降低［(110.48±15.96) mL/min比(120.82±18.92) mL/min,P＝0.000］;24 h尿微量蛋白尿显著增高［(23.58±8.38)mg/24 h比(17.48±7.92)mg/24 h,P＝0.000］。Pearson线性相关性分析显示Hcy与2型糖尿病病人cIMT、动脉硬化指数、动脉硬化指数、冠心病指数和24 h尿微量蛋白尿等显著正相关,与肾小球滤过率显著负相关(P＜0.01)。结论 同型半胱氨酸水平升高是2型糖尿病病人肾和心血管功能损伤的危险因素。 |
| 英文摘要: |
| Objective To investigate the association of homocysteine (Hcy) with renal and cardiovascular function in patients with type 2 diabetes mellitus.Methods From January 2014 to January 2016,120 patients with type 2 diabetes were prospectively collected in the People’s Hospital of Zhoukou.According to serum Hcy levels,all patients were divided into a study group (Hcy≥10μmol/L) and a control group (Hcy＜10 μmol/L).The carotid artery intima-media thickness (cIMT),arteriosclerosis index,coronary heart disease index,glomerular filtration rate,fasting blood glucose,insulin resistance index (HOMA-IR) and insulin function index (HOMA-β).Results When compared with the control group,patients in the study group got a significantly higher level of HOMA-IR (7.48±2.52 vs.6.81±2.53,P＝0.000),a higher level of HOMA-β (67.83±9.29 vs.78.62±11.53,P＝0.000).The fasting blood glucose levels of the two groups were not statistically significant ［(11.81±5.48) mmol/L vs. (11.40±5.93) mmol/L,P＝0.753］.Compared with the control group,patients in the study group got a significantly higher level of cIMT ［(1.31±0.21) mm vs. (1.12±0.18) mm,P＝0.000］,a higher level of arteriosclerosis index (3.93±2.21 vs.2.74±1.83,P＝0.000),a higher level of coronary heart disease index (2.39±0.65 vs.1.92±0.58,P＝0.002),a decrease in glomerular filtration rate ［(110.48±15.96)mL/min vs. (120.82±18.92) mL/min,P＝0.000］ and an increase in 24 hours urine micro albumin quantity ［(23.58±8.38) mg/24 h vs. (17.48±7.92) mg/24 h,P＝0.000］.Pearson linear correlation analysis showed that Hcy was significantly positively correlated with cIMT,arterial stiffness index,coronary heart disease index and 24 hours urine micro albumin quantity,and negatively correlated with glomerular filtration rate (P＜0.01).Conclusion An elevated homocysteine level is a risk factor for renal and cardiovascular risk in patients with type 2 diabetes. |
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