| 程储记,朱敏,陈刚.炎性因子在食管癌根治术后吻合口瘘早期诊断中的价值分析[J].安徽医药,2019,23(6):1195-1198. |
| 炎性因子在食管癌根治术后吻合口瘘早期诊断中的价值分析 |
| Value of inflammatory cytokine in early diagnosis of anastomotic leakage after radical resection of esophageal cancer |
| 投稿时间：2018-10-27 |
| DOI： |
| 中文关键词: 炎性因子 吻合口瘘 食管癌 |
| 英文关键词: Inflammatory cytokine Anastomotic leakage Esophageal cancer |
| 基金项目:安徽医科大学校临床科学研究项目(2015xkj144) |
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| 摘要点击次数: 1545 |
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| 中文摘要: |
| 目的 评价食管癌根治术病人术后血清及胸腔引流液中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平对早期诊断吻合口瘘的意义。方法 选择2017年1月至2018年6月安庆市立医院心胸外科确诊为食管癌并行食管癌根治术的住院病人156例为研究对象,根据是否发生吻合口瘘分为吻合口瘘组(AL组)、非吻合口瘘组(非AL组)。统计两组病人一般情况。分析对比两组病人术前和术后第3天静脉血中白细胞、中性粒细胞百分比、血红蛋白,血清中IL-6、IL-8、IL-10水平,以及两组病人术后第3天胸腔引流液中白细胞、IL-6、IL-8、IL-10水平。结果 156例病人中,13例病人发生吻合口瘘(8.33%)。AL组病人住院时间为51(38,5)d,长于非AL组病人(Z=-5.212,P<0.001),两组病人包括术式在内的其他一般情况差异无统计学意义(均P＞0.05)；两组病人术前和术后第3天静脉血白细胞、中性粒细胞百分比、血红蛋白,术前血清IL-6、IL-8、IL-10以及术后第3天胸腔引流液中白细胞水平均差异无统计学意义(均P＞0.05)。在相同基线水平下,AL组病人术后第3天血清IL-6、IL-8、IL-10水平分别为(367.90±173.78)、(467.95±197.22)、(40.73±10.98) pg/mL,高于非AL组(t=5.847,P<0.001；t=7.956,P<0.001；t=9.018,P<0.001)；AL组病人胸腔引流液中IL-6、IL-8、IL-10水平分别为(1 596.68±291.07)、(1 149.90±228.33)、(30.52±11.00) pg/mL,高于非AL组(t=14.417,P<0.001；t=9.720,P<0.001；t=6.609,P<0.001)。结论 血清及胸腔引流液中IL-6、IL-8、IL-10水平对食管癌根治术后吻合口瘘早期诊断具有一定预测作用。 |
| 英文摘要: |
| Objective To evaluate the significance of interleukin-6 (IL-6),interleukin-8 (IL-8),interleukin-10 (IL-10) levels in serum and thoracic drainage fluid in the early diagnosis of anastomotic leakage (AL) after radical resection of esophageal cancer.MethodsTotally 156 inpatients with esophageal cancer who underwent radical resection of esophageal cancer in Department of Cardiothoracic Surgery of Anqing Municipal Hospital from January 2017 to June 2018 were selected as study subjects.According to the occurrence of AL,they were assigned into AL group and non-AL group.General information of the patients was recorded and compared.The levels of white blood cells in venous blood,the percent of neutrophile granulocyte,hemoglobin in venous blood and IL-6,IL-8,IL-10 in serum before and 3 d after operation as well as 3d postoperative levels of white blood cells,IL-6,IL-8 and IL-10 in thoracic drainage were compared between the two groups.Results AL occurred in 13 of the 156 patients (8.33%).Patients in AL group had longer hospitalization time [51 (38,5) d] than that in non-AL group (Z=-5.212,P<0.001).There were no significant differences in the other general information including surgical options between the two groups (all P>0.05).There were no significant differences in the levels of preoperative and 3d postoperative white bloods cells in venous blood,hemoglobin,preoperative serum IL-6,IL-8,IL-10 and 3d postoperative level of white blood cells in thoracic drainage fluid (all P>0.05).At the same baseline,the levels of IL-6,IL-8 and IL-10 in serum [(367.90±173.78),(467.95±197.22),(40.73±10.98) pg/mL] and in thoracic drainage fluid [(1 596.68±291.07),(1 149.90±228.33),(30.52±11.00) pg/mL] of AL group were higher than those in non-AL group on the third day after operation (t=5.847,P<0.001;t=7.956,P<0.001;t=9.018,P<0.001;t=14.417,P<0.001;t=9.720,P<0.001;t=6.609,P<0.001,respectively).Conclusion The levels of IL-6,IL-8 and IL-10 in serum and thoracic drainage fluid can be predictive in the early diagnosis of anastomotic leakage after radical resection of esophageal cancer. |
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