| 余翔,陆志前.百草枯中毒早期胸部CT表现与临床预后的相关性分析[J].安徽医药,2019,23(6):1214-1217. |
| 百草枯中毒早期胸部CT表现与临床预后的相关性分析 |
| Correlation research on early chest CT and clinical prognosis of paraquat poisoning |
| 投稿时间：2018-03-05 |
| DOI： |
| 中文关键词: 百草枯中毒 胸部CT 磨玻璃影 病变范围 |
| 英文关键词: Paraquat poisoning Chest CT Ground-glass opacity Extent disease |
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| 中文摘要: |
| 目的 探讨百草枯(PQ)中毒早期胸部CT表现与临床预后的关系,为临床病情评估提供依据。方法 选取宣城市人民医院2014年9月至2018年1月确诊为百草枯中毒的病人18例,分为存活组与死亡组,比较两组早期(＜1周)与中期(1~2周)胸部病变区域CT值、是否合并肺外征象及发病年龄的差异；采用Spearman等级相关分析中毒早期肺部病变范围与临床预后的相关性。结果 18例病人存活11例、死亡7例,病死率38.89%；两组年龄、中毒早期肺部病变CT均值、中毒中期肺部病变CT增加值、是否合并肺外征象比较,均差异无统计学意义(均P>0.05),两组中毒 后行多次CT复查的病人中,早期与中期CT均值(Uc=-2.701,P=0.007)和中毒中期胸部损伤范围变化(P=0.033)均差异有统计学意义。 病死率与中毒早期肺部损伤范围呈正相关(rs=0.655,P=0.003)。结论 胸部CT对百草枯中毒病人肺部损伤的显示优势明显,在口服剂量不能获得的情况下,早期胸部CT检查有助于评估病人的中毒程度及预后。 |
| 英文摘要: |
| Objective To analyze the relationship between early chest CT and clinical prognosis of paraquat (PQ) poisoning,so as to provide basis for clinical evaluation of severity of illness.Methods Eighteen patients diagnosed with paraquat poisoning in The People's Hospital of Xuancheng from September 2014 to January 2018 were selected and assigned into survival group and death group.The average value of chest lesion on CT scan,whether combined with extrapulmonary manifestations and the difference of onset ages in the early stage (<1 week) and middle stage (1 to 2 weeks),were compared between survival group and death group. Spearman's rank was adopted to analyze the correlation between early pulmonary lesion range and clinical prognosis after poisoning.Results In 18 cases,11 cases survived and 7 cases died,with a mortality rate of 38.89%.The differences between survival group and death group in onset ages,the average value of chest lesion on CT scan at early stage,the added value of chest lesion on CT scan at middle stage,and whether combined with extrapulmonary manifestations were not statistically significant (all P>0.05).The differences between survival group and death group in the average value of chest lesion on CT scan and the range of lung lesions at mid-stage of poisoning were statistically significant (Uc=-2.701,P=0.007；P=0.033,respectively).The mortality rate was positively correlated with the range of lung injury at early stage of poisoning (rs=0.655,P=0.003).Conclusion The chest CT was found with obvious advantages in showing the pulmonary injury of patients with paraquat poisoning,and early chest CT examination was helpful to the evaluation about the degree of toxicity and prognosis of patients in the case of oral dose not available. |
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