| 王国庆,邹延峰.高尿酸血症及痛风易感基因研究进展[J].安徽医药,2019,23(7):1280-1285. |
| 高尿酸血症及痛风易感基因研究进展 |
| Research progress on hyperuricemia and gout susceptibility genes |
| 投稿时间：2018-05-29 |
| DOI： |
| 中文关键词: 痛风 高尿酸血症 易感基因 |
| 英文关键词: Gout Hyperuricemia Susceptibility gene |
| 基金项目:国家自然科学基金(81373073，81673254) |
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| 摘要点击次数: 2110 |
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| 中文摘要: |
| 痛风是由于体内尿酸的合成与排出失衡所诱发的疾病,而高尿酸血症表现为体内尿酸水平过高,是痛风的过渡阶段。高尿酸血症的造成是因为体内尿酸生成或排出的失衡,最终使得体内尿酸含量高于正常值所致。世界范围的学者对痛风及高尿酸血症基因表现出很大的兴趣,它们有着遗传倾向,并且有很多有价值的发现。尿酸在体内的代谢过程复杂,涉及的基因很广泛。总体可分为尿酸合成过程相关基因和排出过程相关基因。前者过程较为简单,涉及的基因包括核酸核糖焦磷酸合成酶1(PRPS1)以及次黄嘌呤鸟嘌呤磷酸核糖基转移酶(HPRT)；后者过程较为复杂,涉及的基因广泛。笔者将按此分类对它们的易感基因进行综述。 |
| 英文摘要: |
| Gout is a common metabolic disease and hyperuricemia is an important biochemical basis for gout.The development of hyperuricemia is due to the formation and excretion of uric acid in the body,which ultimately results in above the average uric acid levels in the body.Scholars around the world show great interest in genes of gout and hyperuricemia,which have a genetic predisposition,and many valuable discoveries.The metabolic process of uric acid is complex in the body,and the corresponding genes are also extensive,which can be divided into uric acid synthesis related genes and excretion process related genes.The former process is relatively simple.The genes involved include the nucleic acid ribose pyrophosphate synthase 1 (PRPS1) and hypoxanthine guanine phosphoribosyl transferase 1 (HPRT1).The latter process is more complex and involves a wide range of genes.The article will review the susceptibility genes for hyperuricemia and gout according to this classification. |
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