| 李宜敏,余春华.抑郁情绪对肺癌病人化疗后认知功能的影响[J].安徽医药,2019,23(8):1539-1542. |
| 抑郁情绪对肺癌病人化疗后认知功能的影响 |
| Effect of depression on chemotherapy-induced cognitive impairment of lung cancer patients |
| 投稿时间：2017-06-04 |
| DOI： |
| 中文关键词: 肺肿瘤 抑郁 认知障碍 抗肿瘤联合化疗方案/副作用 |
| 英文关键词: Lung neoplasms Depression Cognition disorders Antineoplastic combined chemotherapy protocols/adverse effects |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨抑郁情绪对肺癌病人化疗后认知功能的影响。方法 对四川大学华西医院肿瘤科2017年1—5月期间收治的76例肺癌病人分别在化疗前后采用抑郁自评量表(SDS)和简易精神状况检查表(MMSE)、前瞻性记忆问卷(PM)、回顾性记忆问卷(RM)进行测查。化疗后根据SDS评分,将病人分为抑郁组(34例)、未抑郁组(42例),比较化疗前后抑郁评分及认知神经心理学特征的变化。结果 76例病人顺利完成化疗前后的测试。化疗前病人在SDS、MMSE、PM、RM得分分别是(36.34±7.11)分、(27.52±1.72)分、(18.78±4.24)分、(17.97±4.34)分,化疗后得分分别是(49.21±12.45)分、(26.01±1.78)分、(20.52±3.70)分、(19.50±2.70)分,差异有统计学意义(P＜0.05)。化疗后抑郁组病人在MMSE、PM、RM得分分别是(25.02±1.09)分、(21.56±3.01)分、(21.23±3.21)分,未抑郁组病人得分分别是(27.11±1.47)分、(19.32±4.05)分、(17.50±2.30)分,差异有统计学意义(P＜0.05)。结论 肺癌病人化疗后存在不同程度的认知障碍,且认知障碍与抑郁状态呈正相关。 |
| 英文摘要: |
| Objective To investigate the effects of depression on chemotherapy-induced cognitive impairment(CICI)of lung cancer patients.Methods A total of 76 lung cancer patients admitted to the Oncology Department of West China Hospital of Sichuan University from January to May 2017 were were administered with self-rating depression scale(SDS),mini mental state examination (MMSE),prospective memory (PM) and retrospective memory (RM) questionnaires before and after chemotherapy.After chemotherapy,the patients were divided into the depressed group (34 cases) and the non depressed group (42 cases) according to the SDS.The cognitive test was conducted again,and the scores of depression and cognitive neuropsychological characteristics were compared before and after chemotherapy.Results A total of 76 lung cancer patients completed tests.The scores of SDS,MMSE,PM and RM before chemotherapy were (36.34±7.11),(27.52±1.72),(18.78±4.24) and (17.97±4.34),respectively,and the scores after chemocherapy were (49.21±12.45),(26.01±1.78),(20.52±3.70),and (19.50±2.70),respectively,with statistically significant differences (P<0.05).The scores of MMSE,PM and RM in the depressed group were (25.02±1.09),(21.56±3.01) and (21.23±3.21),respectively,and those in the non-depressed group were (27.11±1.47),(19.32±4.05) and (17.50±2.30),respectively,with statistically significant differences (P<0.05).Conclusion Lung cancer patients have different levels of cognitive impairment after chemotherapy,and cognitive impairment of patients is positively correlated with depression. |
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