| 张莉,刘菊菊.阿托西班治疗先兆早产80例疗效观察[J].安徽医药,2019,23(8):1677-1680. |
| 阿托西班治疗先兆早产80例疗效观察 |
| Therapeutic effect of atosiban on 80 cases of threatened premature delivery |
| 投稿时间：2018-01-15 |
| DOI： |
| 中文关键词: 早产 阿托西班 安胎 催产素 宫缩抑制 妊娠结局 |
| 英文关键词: Premature birth Atosiban Miscarrige prevention Oxytocin Contraction inhibition Pregnancy outcome |
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| 中文摘要: |
| 目的 观察不同疗程阿托西班治疗先兆早产的疗效及安全性。方法 2017年5月至2018年5月南京医科大学附属妇产医院诊断为先兆早产孕妇80例,按照随机数字表法分为长疗程组和短疗程组各40例,其中长疗程组接受45 h阿托西班静脉注射,短疗程组接受18 h阿托西班静脉注射,阴道超声测量病人宫颈长度(CL)。观察两组48 h和7 d的宫缩抑制效果,比较各组中不同CL病人疗效差异,统计不良反应和妊娠结局。结果 长疗程组48 h和7 d宫缩抑制率分别为85.0%和72.5%,显著高于短疗程组的65.0%和45.0%,差异有统计学意义(P＜0.05),两组分娩时孕周差异无统计学意义[(33.17±3.58)比(32.92±3.16),P＞0.05]。长疗程组CL≥20 mm病人48 h和7 d宫缩抑制率分别为95.2%和81.0%,长疗程组CL＜20 mm病人相应指标为73.7%和63.2%,两组差异无统计学意义(P＞0.05),短疗程组CL≥20 mm病人48 h和7 d宫缩抑制率分别为81.8%和68.2%,显著高于短疗程组CL＜20 mm病人的44.4%和16.7%(P＜0.05)。两组病人在不良反应、保胎成功率、新生儿体质量和1 min Apgar评分方面均差异无统计学意义(P＞0.05)。结论 阿托西班可有效延长先兆早产妊娠时间,长疗程方案更加有效且不增加母婴不良反应,对于CL＜20 mm病人应使用阿托西班长疗程用药方案。 |
| 英文摘要: |
| Objective To observe the efficacy and safety of different therapeutic regimen of Atosiban for treating preterm labor.Methods Eighty cases of pregnant women with preterm labor in Women's Hospital of Nanjing Medical University from May 2017 to May 2018 were randomly assigned into long therapeutic regimen group and short therapeutic regimen group according random number table,with 40 cases in each group.Group Areceived 45 h intravenous injection of Atosiban,while short therapeutic regimen group received 18 h with same drug.Vaginal ultrasound was used to measure all patient's cervix length (CL).The effect of contraction inhibition at 48 h and 7 d between the two groups was compared,and the effect of patients with CL≥20 mm or CL＜20 mm in each group was observed.Furthermore adverse reactions and pregnancy outcomes of both were recorded.Results The inhibition rate of contraction at 48 h and 7 d in long therapeutic regimen group was 85.0% and 72.5%,respectively,which was significantly higher than 65.0% and 45.0% in short therapeutic regimen group,the difference was statistically significant (P＜0.05).There was no significant difference in the gestational age between the two groups [(33.17±3.58) vs.(32.92±3.16),P＞0.05].In long therapeutic regimen group,patients with CL≥20 mm had a contraction inhibition rate of 95.2% and 81.0% at 48 h and 7 d,respectively,and those with CL＜20 mm were 73.7% and 63.2%,respectively,and there was no significant difference between the two groups (P＞0.05).In short therapeutic regimen group,patients with CL≥20 mm had a contraction inhibition rate of 81.8% and 68.2% at 48 h and 7 d,respectively,which were significantly higher than 44.4% and 16.7% in patients with CL＜20 mm,respectively (P＜0.05).There were no significant differences in adverse reactions,the success rate of pregnancy,neonatal weight and 1 min Apgar score between the two groups (P＞0.05).Conclusion Atosiban can effectively prolong the time of aura premature gestation,the long therapeutic regimen is more effective which does not increase maternal and infant adverse reactions.For patients with CL＜20 mm long therapeutic regimen was recommended. |
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