| 张洋洋,高劲,陶振超,等.高级别胶质瘤病人放化疗前后淋巴细胞亚群变化及意义[J].安徽医药,2019,23(10):2032-2035. |
| 高级别胶质瘤病人放化疗前后淋巴细胞亚群变化及意义 |
| Changes of lymphocyte subsets in patients with high grade glioma before and after chemoradiotherapy and its significance |
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| DOI：10.3969/j.issn.1009?6469.2019.10.032 |
| 中文关键词: 胶质瘤 CD4淋巴细胞计数 CD8阳性 T淋巴细胞 CD4?CD8比值 白细胞介素 2受体 α亚单位 预后 |
| 英文关键词: Glioma CD4 lymphocyte count CD8?positive T?lymphocytes CD4-CD8 ratio Interleukin?2 receptor alpha subunit Prognosis |
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| 中文摘要: |
| 目的探讨高级别胶质瘤( high grade glioma，HGG)术后病人同步放化疗前后外周血淋巴细胞亚群变化及其对预后的影响。方法收集 2012年 6月至 2017年 7月间安徽省肿瘤医院收治的 51例 HGG术后病人为研究对象，检测同步放化疗前后病人外周血淋巴细胞亚群变化，并依据同步放化疗前 CD4+/CD8+比值将病人分为 CD4+/CD8+≥1及 CD4+/CD8+＜1两组，采用 Ka? plan?Meier法计算无进展生存率( progression?free survival，PFS、总生存率( overall survival，OS)以及中位无进展生存期( median progression?free survival，mPFS)和中位总生存期( median overall survival，mOS)。结果 HGG术后病人外周血 CD4+CD25+细胞水平及 CD4+/CD8+比值经同步放化疗后均有下降( P＜0.05)。其余指标差异无统计学意义。中位随访时间 14个月，范围为 2~ 60个月， 2例失访。 1、2、3年全组病人 PFS和 OS分别为 51.8%，38.3%，31.9%和 71.3%，43.3%，37.2%。CD4+/CD8+≥1组病人 mPFS及中位 mOS均高于 CD4+/CD8+＜1组( 16个月比 9个月， P＝0.004；36个月比 11个月， P＝0.031)。结论同步放化疗可降低 HGG病人外周血 CD4+CD25+细胞水平及 CD4+/CD8+比值；放化疗前 CD4+/CD8+比值可以作为评价 HGG术后病人预后的有效指标， CD4+/CD8+比值低，预后差。 |
| 英文摘要: |
| Objective To explore the relationship between changes of lymphocyte subsets in patients with high grade glioma afterconcurrent chemoradiotherapy，and to analyze its influence on prognosis.Methods A total of 51 patients with postoperative highgrade glioma who admitted to Anhui Provincial Cancer Hospital from June 2012 to July 2017 were choose as study objects.Thechanges of lymphocyte subgroups were detected before and after chemoradiotherapy.Based on CD4+/CD8+ ratio before chemoradio? therapy，patients with high grade glioma were assigned into two groups:CD4+/CD8+≥1 and CD4+/CD8+＜1.The progression free sur? vival(PFS)，overall survival(OS)，median progression?free survival(mPFS)and median overall survival(mOS)were calculated by the Kaplan?Meier method.Results The lever of CD4+CD25+ and the ratio of CD4+/CD8+ were decreased in patients with postop? erative high grade glioma after chemoradiotherapy(P＜0.05).The difference of the other indicators was not statistically significant. The median follow?up time was 14 months(2?60 months)，two patients were lost to follow?up.PFS rates in the 1?，2?，and 3?year were 51.8%，38.3% and 31.9%，respectively，and OS rates was 71.3%，43.3% and 37.2%，respectively.mPFS and mOS in CD4+/CD8+≥1 group were higher than those of CD4+/CD8+＜1 group(16 months vs.9 months，P＝0.004；36 months vs.11 months，P＝ 0.031).Conclusions The lever of CD4+CD25+ and the ratio of CD4+/CD8+ were decreased in the HGG patients after chemoradio? therapy.The ratio of CD4+/CD8+ before radiotherapy can be considered as an index to evaluate prognosis in patients with postopera?tive high grade glioma.The prognosis is poor in patients with low raito of CD4+/CD8+. |
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