| 高鲁,李仲颖,刘飞,等.早期肠内营养联合益生菌对重度颅脑外伤病人免疫功能的影响[J].安徽医药,2019,23(10):2047-2049. |
| 早期肠内营养联合益生菌对重度颅脑外伤病人免疫功能的影响 |
| Influence of early enteral nutrition combined with probiotics treatment on immunologic function in patients with severe craniocerebral traum |
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| DOI：10.3969/j.issn.1009?6469.2019.10.036 |
| 中文关键词: 颅脑损伤 有益菌种 肠道营养 免疫功能 |
| 英文关键词: Craniocerebral trauma Probiotics Enteral nutrition Immunologic function |
| 基金项目: |
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| 中文摘要: |
| 目的探讨早期肠内营养联合益生菌对重度颅脑外伤病人免疫功能的影响。方法选取 2015年 3月至 2017年 3月安徽医科大学第一附属医院收治的重度颅脑外伤病人 64例，采用随机数字表法分为观察组 32例和对照组 32例，观察组采用早期肠内营养联合益生菌治疗，对照组采用肠外营养治疗，比较 1周后两组肺部感染、尿路感染、消化道出血的发生率以及免疫功能指标情况。结果 1周后观察组肺部感染、尿路感染、消化道出血发生率低于对照组，观察组白细胞介素 ?6(IL?6)(42.21± 5.4)pg/mL、CD4+T细胞数量( 42.34±4.24)×106/L高于对照组 IL?6(20.16±4.38)pg/mL、CD4+T细胞数量( 37.32±4.89)×106/L，观察组 CD8+T细胞数量(27.22±3.67)×106/L低于对照组 CD8+T细胞数量( 34.28±4.28)×106/L，均差异有统计学意义( P＜0.05)；观察组 C反应蛋白( CRP)含量( 20.12±3.45)mg/L、乳酸含量( 3.28±0.86)mmol/L与对照组 CRP含量( 24.26±2.84)mg/L、乳酸含量(3.49±0.72)mmol/L差异无统计学意义( P＞0.05)。结论重度颅脑外伤病人早期肠内营养联合益生菌治疗可以减少并发症，改善免疫功能。 |
| 英文摘要: |
| Objective To investigate the effect of early enteral nutrition combined with probiotics treatment on immunologic func?tion in patients with severe craniocerebral trauma.Methods Sixty?four cases of severe craniocerebral trauma patients who were ad?mitted to the First Affiliated Hospital of Anhui Medical University from March 2015 to March 2017 were randomly assigned intotwo groups:experiment group，control group，with 32 patients in each group.Experiment group patients were treated with early enter? al nutrition combined with with probiotics，while control group patients were treated with parenteral nutrition.The incidence of pul? monary infection，urinary tract infection，gastrointestinal bleeding and immune function were compared between two groups after 1 week.Results After one week，the incidence of pulmonary infection，urinary tract infection，gastrointestinal bleeding in the experi? ment group were lower than that in the control group.IL?6 serum level(42.21±5.4)pg/mL and CD4+T cells counts(42.34±4.24)× 106/L in the experiment group were higher than(20.16±4.38)pg/mL of IL?6 serum level and(37.32±4.89)×106/L of CD4+T cells counts in the control group.CD8+T cells counts(27.22±3.67)×106/L in experiment group were lower than(34.28±4.28)×106/L of control group，and the difference was statistically significant(P＜0.05).The differences of CRP serum level and lactic acid serum level in the experiment group and the control group were no significant difference［CRP serum level:(20.12±3.45)mg/L vs.(24.26± |
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