| 刘蒙蒙,方朝晖.皮肤晚期糖基化终末产物水平及血浆同型半胱氨酸变化与 2型糖尿病伴大血管病变的关系[J].安徽医药,2019,23(11):2156-2158. |
| 皮肤晚期糖基化终末产物水平及血浆同型半胱氨酸变化与 2型糖尿病伴大血管病变的关系 |
| Correlation research between skin advanced glycation end products， plasma HCY and large vascular diseases in type 2 diabetes mellitus |
| |
| DOI：10.3969/j.issn.1009?6469.2019.11.009 |
| 中文关键词: 糖尿病血管病变 糖基化终产物，高级 同型半胱氨酸 皮肤 |
| 英文关键词: Diabetic angiopathies Glycation end products,advanced Homocysteine Large vascular diseases Skin |
| 基金项目:国家自然科学基金面上项目(81774286) |
|
| 摘要点击次数: 2076 |
| 全文下载次数: 675 |
| 中文摘要: |
| 目的分析 2型糖尿病伴大血管病变( DMP)病人皮肤晚期糖基化终末产物( SAGE)水平、血浆同型半胱氨酸( HCY)变化及其临床意义。方法选择 2017年 1月至 2018年 6月于安徽中医药大学第一附属医院住院的 2型糖尿病病人 70例，依据是否合并大血管病变将其分为 DMP组和无 DMP组( NDMP组)各 35例，同时选取同时期体检健康人群 35例作为正常对照组( NC组)收集各组一般资料，测定各组 SAGE、和HCY水平并进行比较。结果 NC组SAGE(58.34±6.46)AU、HCY(9.73±4.72)μmol/L、三酰甘，油( 1.09±0.23)mmol/L、总胆固醇水平( 3.93±0.57)mmol/L，NDMP组 SAGE(67.02±5.14)AU、HCY(21.66±6.70)μmol/L、三酰甘油(1.60±0.42)mmol/L、总胆固醇水平( 4.47±1.01)mmol/L，与 NC组相比， NDMP组明显升高( t值分别为 6.027，8.166，5.881，2.616，P＜0.01)；与 NDMP组相比， DMP组 SAGE水平( 90.85±8.79)AU明显增高( t值为 13.851，P＜0.01)两组 HCY、三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白水平均差异有统计学意义( t值分别为 10.793，6.208，8.137， .412，P＜3.997，9，0.01)。结论 2型糖尿病病人 SAGE、HCY水平升高、血脂代谢紊乱可能参与糖尿病大血管病变的发生。 |
| 英文摘要: |
| Objective To investigate and analyze the correlation between skin advanced glycation end products(SAGEs)，plasmaHCY and large vascular diseases in type 2 diabetes mellitus.Methods A total of 70 cases of patients with type 2 diabetes melli?tus from our hospital from January 2017 to June2018 were selected and divided into the macrovascular disease group(DMP group， n＝35)and the group without macrovascular disease(NDMP group，n＝35).Another 30 cases of healthy controls in our hospitalfor physical examination in the same period were selected as the control group.The clinical data，SAGEs and plasma HCY levels of the three groups were statistically analyzed.Results Compared with NC group，SAGE［( 58.34±6.46)AU vs.(67.02±5.14)AU］， HCY［( 9.73±4.72)μmol/L vs.(21.66±6.70)μmol/L］，TG［( 1.09±0.23)mmol/L vs.(1.60±0.42)mmol/L］and TC levels［( 3.93±0.57)mmol/L vs.(4.47±1.01)mmol/L］of patients in NDMP group were significantly increased(The t values were 6.027，8.166，5.881，2.616 respectively，P＜0.01).Compared with NDMP group，SAGE level［( 90.85 ± 8.79)AU］of patients in DMP group was significantly increased(The t value was 13.851，P＜0.01)，and there was an obvious difference in blood lipid level(TG，TC，HLDL，LDL)and HCY level between the two groups(The t values were 6.208，8.137，3.997，9.412 and 10.793，respectively，P＜0.01). Conclusion Elevated level of SAGE and HCY and disorder of lipid metabolism in patients with type 2 diabetes may be involved in the occurrence of large vascular diseases. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
