| 候斐,张琳,高琳,等.妊娠糖尿病病人血清 25?羟维生素 D与糖化血红蛋白及胰岛素抵抗的相关性分析[J].安徽医药,2019,23(11):2163-2165. |
| 妊娠糖尿病病人血清 25?羟维生素 D与糖化血红蛋白及胰岛素抵抗的相关性分析 |
| Correlation of serum 25?hydroxyvitamin D with hemoglobin a1c and insulin resistance in patients with gestational diabetes mellitus |
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| DOI：10.3969/j.issn.1009?6469.2019.11.011 |
| 中文关键词: 妊娠糖尿病 25?羟维生素 D 胰岛素抵抗 血红蛋白 A，糖基化 |
| 英文关键词: Gestational diabetes mellitus 25?OH?Vit D Insulin resistance Hemoglobin A,glycosylated |
| 基金项目:国家自然科学基金资助项目( 81660142) |
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| 中文摘要: |
| 目的探讨妊娠糖尿病( GDM)病人血清 25?羟维生素 D(25?OH?Vit D)水平的变化与糖化血红蛋白( HbA1C)及胰岛素抵抗( IR)的相关性。方法收集 2016年 9月至 2017年 9月遵义医学院附属医院就诊的 GDM病人 123例，按照不同的 25?OH?Vit D水平进行分组，维生素 D严重缺乏组即 Vit?SD组( 25?OH?Vit D＜10 ng/mL)及维生素 D非严重缺乏组即 Vit?NSD组( 25?OH? Vit D≥10 ng/mL)，比较不同组别病人的临床资料，并对 25?OH?Vit D与 HbA1C及胰岛素抵抗的相关性进行分析。结果 Vit?SD组中 HbA1C［(6.28±1.23)%比( 5.66±0.60)%］、 FPG［(5.95±0.61)mmol/L比( 5.52±0.77)mmol/L］、 FINS(12.50 U/mL比 8.90 U/ mL)和 HOMA?IR(3.26比 2.26)高于 Vit?NSD组，差异有统计学意义( P＜0.05)；血清 25?OH?Vit D的水平与 FPG、FINS、HOMA?IR呈负相关( r＝-0.335，r＝-0.381，r＝-0.448)相关性差异有统计学意义( P＝0.011，P＝0.006，P＝0.001)。结论妊娠期间维生素 D的缺乏与其糖代谢异常和 IR有关， GDM病，人予以适当补充维生素 D制剂，有助于改善其血糖水平及胰岛素抵抗情况。 |
| 英文摘要: |
| Objective To investigate the correlation between serum level of 25?OH?Vit D and HbA1C and insulin resistance in pa? tients with gestational diabetes mellitus.Methods A total of 123 gestational diabetes mellitus(GDM)patients admitted to the af?filiated hospital of Zunyi medical college from September 2016 to September 2017 were collected and analyzed.The clinical data ofpatients in different groups were compared and the correlation between 25?OH?Vit D and HbA1Cand insulin resistance was analyzed. Vitamin D deficiency was defined as Vit?SD(25?OH?Vit D＜10ng/ml)and Vit?NSD(25?OH?Vit D＞10 ng/mL).Results Vit? SD group and Vit?NSD group had higher HbA1C［( 6.28 ± 1.23)% vs.(5.66 ± 0.60)%］，fasting glucose［( 5.95 ± 0.61)mmol/L vs.(5.52±0.77)mmol/L］，fasting insulin(12.50 U/mL vs. 8.90 U/mL)and HOMA?IR(3.26 vs. 2.26)than Vit?NSD group，and the dif? ference was statistically significant(P＜0.05).Serum level of 25?OH?Vit D was negatively correlated with fasting glucose，fasting in? sulin and HOMA?IR(r＝-0.335，r＝-0.381，r＝-0.448)，and the correlation was statistically significant(P＝0.011，P＝0.006，P＝ 0.001).Conclusion Vitamin D deficiency during pregnancy is associated with abnormal glucose metabolism and IR.AppropriateVitamin D supplements in GDM patients may help to improve their blood glucose levels and insulin resistance. |
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