| 孙芳园,许开亮,袁林,等.脓毒症病人血清肌腱蛋白 C的临床意义和预后[J].安徽医药,2019,23(11):2215-2219. |
| 脓毒症病人血清肌腱蛋白 C的临床意义和预后 |
| Clinical significance and prognosis of serum Tenascin?C in patients with sepsis |
| |
| DOI：10.3969/j.issn.1009?6469.2019.11.024 |
| 中文关键词: 脓毒症 肌腱蛋白 C 预后 C反应蛋白质 白细胞介素 6 肿瘤坏死因子 α |
| 英文关键词: Sepsis Tenascin?C Prognosis C?reactive protein Interleukin?6 Tumor necrosis factor?alpha |
| 基金项目:上海市卫生和计划生育委员会中医特色诊疗技术提升项( zyjx?2017021)；上海中医药大学预算内科研项目( 18LK068)；浦东新区中医药研发与创新专项(PDZYYFCX?201801)；浦东新区卫生系统优秀青年医学人才培训计划(PWRq2017?01)；上海市第七人民医院七院新星项目( XX2018?02) |
|
| 摘要点击次数: 2072 |
| 全文下载次数: 634 |
| 中文摘要: |
| 目的探讨肌腱蛋白 C(Tenascin?C)水平与脓毒症病情严重程度的相关性。方法选择 2016年 1月至 2017年 6月上海中医药大学附属第七人民医院收治的脓毒症病人 174例，入院 24 h内收集血液样本，采用酶联免疫吸附法( ELISA)检测血清 Tenascin?C的水平。观察 30 d内病死率。同时选取 80名性别和年龄相匹配的健康献血者为健康对照组。结果脓毒症病人血清 Tenascin?C水平(中位数为 57.1 ng/L)明显高于健康对照组(中位数为 24.1 ng/L)。在 30 d内死亡的脓毒症病人有 60例(34.5%)在脓毒症病人中，死亡组血清 Tenascin?C水平(中位数为 64.9 ng/L)明显高于存活组(中位数为 52.1 ng/L)(P＜ 0.001)毒症病人血清 Tenascin?C水平与脓毒症相关器官衰竭评估( SOFA)评分、血清肌酐、 C反应蛋白( CRP)、白细胞介素 6(IL?6)和肿瘤坏死因子 α(TNF?α)呈正相关(均 P＜0.05)。 Logistic多因素回归模型显示血清 Tenascin?C的水平是 30 d病死率的独立因素。 Kaplan?Meier曲线表明，血清 Tenascin?C水平较高的脓毒症病人( ≥56.9 ng/L)其在 30 d内的病死率高于血清 。脓，Tenascin?C较低者(＜ 56.9 ng/L)(P＜0.001)。结论脓毒症病人具有升高的血清 Tenascin?C，并，与病情严重程度和较差的预后相关。 |
| 英文摘要: |
| Objective To explore the correlation between the level of serum Tenascin?C and the severity and prognosis of patients with sepsis.Methods 174 patients with sepsis admitted to ICU were selected，and blood samples were collected within 24 hours af?ter admission.Serum Tenascin?C level was detected by enzyme?linked immunosorbent assay(ELISA).The 30?day mortality rate was observed.Results The levels of serum Tenascin?C in patients with sepsis were significantly higher than those in the healthy con? trol group(P＜0.001).In 60 cases(34.5%)died within 30 days of the sepsis patients，the serum Tenascin?C levels were higher than those of survivors(P＜0.001).In sepsis patients，serum Tenascin?C level was positively correlated with SOFA score，serum cre? atinine，C reactive protein(CRP)，interleukin 6(IL?6)and tumor necrosis factor alpha(TNF? alpha)( All P＜0.05).The Logisticmultivariate regression model showed that the level of serum Tenascin?C was an independent factor in the mortality rate of 30 days.The Kaplan?Meier curves show that septic patients with high serum Tenascin?C levels(≥56.9 ng/L)demonstrated significantly high? er 30 day mortality rate than those of patients with low serum Tenascin?C(＜ 56.9 ng/L)( P＜0.001).Conclusion Septic patients are with elevated serum Tenascin?C，which are associated with the severity and poor prognosis of the disease. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
