| 王玉梅,刘博,张莉,等.十全大补汤联合肠内营养支持对老年胃癌术后气血两虚证病人营养状况和免疫功能的影响[J].安徽医药,2019,23(11):2270-2274. |
| 十全大补汤联合肠内营养支持对老年胃癌术后气血两虚证病人营养状况和免疫功能的影响 |
| Effect of shiquandabu decoction combined with enteral nutrition support on the nutritional status and immune function of postoperative elderly patients with deficiency of both Qi and Blood syndrome of gastric cancer |
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| DOI：10.3969/j.issn.1009?6469.2019.11.040 |
| 中文关键词: 胃肿瘤 肠道营养 十全大补汤 气血两虚证 中西医结合 老年人 |
| 英文关键词: Stomach neoplasms Enteral nutrition Shiquandabu decoction Deficiency of both qi and blood Integrated tra? ditional Chinese and western medicine gastric cancer Elderly |
| 基金项目:河北省中医药管理局科研计划项目( 2017294) |
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| 中文摘要: |
| 目的探讨十全大补汤联合肠内营养支持对老年胃癌术后气血两虚证病人营养状况和免疫功能的影响。方法选取 2016年 1月至 2017年 12月邯郸市第一医院老年胃癌手术后气血两虚证病人 76例，按照随机数字表法分为观察组 38例和对照组 38例。对照组给予常规肠内营养支持治疗，观察组在对照组基础上辅助使用中药十全大补汤，给予中西医结合肠内营养支持治疗。经治疗后，比较两组病人肠鸣音恢复时间及排气、排便时间。对比两组病人在治疗前、治疗第 8天后病人的营养状况和免疫功能指标的变化情况。结果观察组在术后肠鸣音恢复时间( 41.2±5.2)h及排气( 69.5±7.8)h、排便时间( 81.5±9.8)h上显著快于对照组( 49.5±6.5)h、(73.6±8.6)h、(88.2±10.5)h，差异有统计学意义( P＜0.05)。治疗 8d后，观察组总蛋白( TP)(64.09±5.07)g·L-1、转铁蛋白( TRF)(2.10±0.18)g·L-1及血红蛋白( Hb)(117.59±14.32)g·L-1上升幅度均显著高于对照组(61.16±5.01)、(1.99±0.19)、(110.45±16.42)g·L-1(P＜0.05)；观察组血清 IgA、IgG、IgM水平升高幅度均显著高于对照组( P＜ 0.05)。两组病人治疗 8d后 CD4+均升高( P＜0.05)但观察组高于对照组( P＜0.05)；两组病人 CD8+均降低( P＜0.05)，但观察组低于对照组( P＜0.05)；两组病人 CD4+/CD8+P＜0.05)，但观察组高于对照组( P＜0.05)。结论对于老年胃癌术后气血两虚证病人，运用中西医结合理念，应用十全大补汤联合肠内营养支持不仅可在一定程度上促进肠功能恢复、改善机体营均提升(，养状况，而且还能提高机体免疫力，起到了促进病人早日康复的目的。 |
| 英文摘要: |
| Objective To explore the effect of shiquandabu decoction combined with enteral nutrition support on the nutritional sta? tus and immune function of postoperative elderly patients with deficiency of both Qi and Blood syndrome of gastric cancer.Methods 76 elderly patients with deficiency of both Qi and Blood syndrome of gastric cancer in Handan First Hospital from January 2016 toDecember 2019 0were selected and randomly divided into the observation group 38 cases and the control group 38 cases.The pa?tients of the control group were given conventional enteral nutrition support treatment，on this basis，the patients of the observation group were supplemented the shiquandabu decoction，using Integrated Traditional Chinese and Western Medicine enteral nutrition support treatment.After treatment，the recovery time of bowel sounds，exhaust time and defecation time were compared.Changes in nu?tritional status and immune function indicators were compared between the two groups before and after treatment on day 8.Results The observation group were significantly faster than the control group in the recovery time of postoperative bowel sounds［( 41.2± 5.2)h vs.(49.5±6.5)h］，the exhaust［(69.5±7.8)h vs.(73.6±8.6)h］and defecation time［(81.5±9.8)h vs.(88.2±10.5)h］and the difference were statistically significant(P0.05).After 8 days treatment，TP［( 64.09 ±5.07)g·L-1 vs.(61.16± 5.01)g·L-1］，TRF［( 2.10±0.18)g·L-1 vs.(1.99±0.19)g·L-1］and Hb［( 117.59±14.32)g·L-1 vs.(110.45±16.42)g·L-1］of the observation group were higher than that of the control group and the difference were statistically significant(P＜0.05).Meanwhile，IgA，IgG，IgM of the observation group were better than those of the control group，the difference was statistically significant(P＜0.05).After 8 days treat? ment，CD4+ was increased in both groups(P＜0.05)，however，the optimal control group in the observation group(P＜0.05)； CD8+ was decreased in both groups(P＜0.05)，but the observation group was superior to the control group(P＜0.05).CD4+/CD8+ was in? creased in both groups(P＜0.05)，but the observation group was superior to the control group(P＜0.05).Conclusion For postop? erative elderly patients with deficiency of both Qi and Blood syndrome of gastric cancer，guiding by Integrated Traditional Chinese and Western Medicine idea，the application of shiquandabu decoction combined with enteral nutrition support not only can promotethe intestinal function recovery and improve the nutritive condition of the body，but also can improve the body immunity.This method serves to promote the patient’s early recovery. |
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