| 吴勤研,王楠,冷静,等.右雷佐生在预防表柔比星心脏毒性时使用的合理性分析[J].安徽医药,2019,23(11):2296-2298. |
| 右雷佐生在预防表柔比星心脏毒性时使用的合理性分析 |
| Rationality analysis of the use of dexrazoxane in epirubicin chemotherapy |
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| DOI：10.3969/j.issn.1009?6469.2019.11.047 |
| 中文关键词: 右雷佐生 表柔比星 心脏毒性 化疗 合理用药 |
| 英文关键词: Dexrazoxane Epirubicin Cardiac Toxicity Chemotherapy Patients The rational use of drugs |
| 基金项目:江苏省药学会?奥赛康医院药学基金资助项目( A201707) |
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| 中文摘要: |
| 目的调查分析右雷佐生( DEX)在预防表柔比星心脏毒性时的使用情况，促进临床合理的用药。方法提取东部战区总医院 2017年 7月 1日至 12月 31日肿瘤病人化疗方案中使用到表柔比星的病例，其中使用到右雷佐生的，参照药品说明书和蒽环类药物心脏毒性防治指南( 2013年版)的规定，对其用药人群、用药时机、用药剂量等因素进行分析。结果 2017年下半年有 148例共计 672次使用到表柔比星。有 56例共计 234次使用了右雷佐生且均为乳腺癌病人，占到乳腺癌病人总化疗次数(324次)的 72.22%，其中，有 28例共计 158次首次化疗即使用右雷佐生，占到使用右雷佐生化疗次数( 234次)的 67.52%；有 206例次右雷佐生稀释浓度在规定的范围内，所占比例为 88.03%。结论临床医生在使用右雷佐生时还存在一定的不规范现象，审方药师应不断提高业务能力，切实发挥审核处方的作用，促进临床合理用药。 |
| 英文摘要: |
| Objective To investigate and analyze the use of dexrazoxane(DEX)in the prevention of epirubicin heart toxicity in our hospital，and promote the rational use of the drug in clinic.Methods The cases of epirubicin used in the chemotherapy pro?gram of patients with tumors in the second half of 2017 in Eastern Theater General Hospital were analyzed.Among them，the pa?tients who use DEX were selected.Based on the provisions of the drug manual and the guidelines for the prevention and treatmentof cardiac toxicity of anthracyclines(2013 edition)，the factors such as population，timing and dosage were analyzed.Results In the second half of 2017，a total of 672 times were used by 148 people.There were 56 patients who used DEX 234 times，all of whom were breast cancer patients，accounting for 72.22% of the total number of chemotherapy(324 times)of breast cancer pa? tients.Among them，there were 28 patients who used DEX for 158 times of first chemotherapy，accounting for 67.52% of the number of chemotherapy using DEX(234 times).There were 206 cases with diluent concentration dilution concentration within the pre? scribed range，accounting for 88.03%.Conclusion There are some irregularities in the use of DEX by clinicians.The prescriptionpharmacist should constantly improve their operational capacity，give full play to the role of prescription review，and promote ratio? nal clinical medication. |
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