| 黄燕,潘旭东,林雄,等.益肾降糖胶囊水提液澄清工艺的优选[J].安徽医药,2019,23(12):2356-2361. |
| 益肾降糖胶囊水提液澄清工艺的优选 |
| Optimization of clarification process for the water?extraction solution of Yishen Jiangtang capsule |
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| DOI：10.3969/j.issn.1009?6469.2019.12.006 |
| 中文关键词: 中草药 提取法 胶囊 益肾降糖胶囊 壳聚糖 芍药苷 二苯乙烯苷 工艺学，制药 澄清工艺 |
| 英文关键词: Drugs,Chinese herbal Extraction Capsules Yishen Jiangtang capsule Chitosan Paeoniflorin Stilbene glucoside Technology,pharmaceutical Clarification Process |
| 基金项目:福建省科技厅引导性项目(2018Y0044) |
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| 中文摘要: |
| 目的优选益肾降糖胶囊提取液的澄清工艺。方法以芍药苷、二苯乙烯苷含量及干浸膏得率为综合评价指标，选择药液比、壳聚糖加入量、絮凝温度、搅拌时间为考察因素，设计正交试验优选益肾降糖胶囊的壳聚糖澄清工艺；同时采用单因素法优选益肾降糖胶囊的醇沉工艺。结果益肾降糖胶囊提取液最佳的澄清工艺为壳聚糖絮凝工艺，即药液比 1∶2，絮凝温度 60 ℃，搅拌时间 20 min，每 1克药材加入壳聚糖 0.4 mL。结论壳聚糖澄清剂处理益肾降糖胶囊水提液的澄清效果良好。优选的澄清工艺稳定可行，适合于益肾降糖胶囊的制备。 |
| 英文摘要: |
| Objective To optimize clarification process for the extract of Yishen Jiangtang capsule.Methods The content of pae? oniflorin and stilbene glucoside and extract yield was comprehensively evaluated.The solid?liquid ratio，the amount of chitosan，floc? culation temperature and stirring time were selected as factors to be investigated.The orthogonal test was adopted to optimize clarifi?cation process of Yishen Jiangtang capsule by chitosan.The single factor method was adopted to optimize the clarification process for the extract of Yishen Jiangtang capsule by alcohol.Results The best clarification process for the water?extraction solution of Yishen Jiangtang capsule was chitosan flocculation process，solid?liquid ratio was 1∶2，the flocculation temperature was 60 ℃，the stirring time was 20 min，and chitosan was added to 0.4 mL per 1 g of medicinal material.Conclusions Clarification effect of chi? tosan as clarifying agent for the water?extraction solution of Yishen Jiangtang capsule is effective.The optimized process is stable and feasible，and it is suitable for preparation of Yishen Jiangtang capsule. |
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