| 张婷婷,唐胜利,谢雷,等.足月妊娠激活素 A和急性胎儿窘迫的关联关系探讨[J].安徽医药,2019,23(12):2471-2475. |
| 足月妊娠激活素 A和急性胎儿窘迫的关联关系探讨 |
| The predictive value of active A for acute fetal distress in term pregnancy |
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| DOI：10.3969/j.issn.1009?6469.2019.12.035 |
| 中文关键词: 胎儿窘迫 激活素类 血气分析 因果律 |
| 英文关键词: Fetal distress Activins Blood gas analysis Causality |
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| 中文摘要: |
| 目的探讨临产时母血、脐血激活素 A水平和急性胎儿窘迫的关联关系。方法选取 2017年 11月至 2018年 5月在安徽医科大学附属妇幼保健院产科病房收治的 121例孕妇，临产后按急性胎儿窘迫诊断标准分为分为急性胎儿窘迫组(n＝52)和健康对照组(n＝69)采用双抗体夹心(ABC?ELISA)法测定母血、脐血激活素 A水平及新生儿脐动脉血气 PH水平，分析激活素 A与急性胎儿窘迫之间，的相关性。结果窘迫组与对照组新生儿在孕龄、体质量及性别方面均差异无统计学意义(P＞0.05)分娩方式上差异有统计学意义(P＜0.05)。而不同分娩方式对母血激活素 A影响差异无统计学意义(P＞0.05)。窘迫组母血、，脐血激活素 A水平为(348.62±233.14)ng/mL、(35.56±39.80)ng/mL，对照组母血、脐血激活素 A水平为(34.04±22.75)ng/mL、(2.93±3.29)ng/mL，两组比较差异有统计学意义(P＜0.05)；窘迫组新生儿相对于对照组脐血 PH低［(7.19±0.11)比(7.25± 0.06)］、碱剩余负值高［ -5.96±4.42)mmol/L比(-4.42±2.78)mmol/L］及血二氧化碳分压(PCO2)高［(59.25±13.59)mmHg比(51.72±7.96)mmHg］均差异有统计学意义(P＜0.05)而血氧分压(PO2)低于对照组，差异无统计学意义(P＞0.05)。窘迫组母血、脐血激活素A水平，与脐动脉 PCO2均存在显著正相关，(r＝0.370、0.200，均 P＜0.05)；与新生儿 PH及碱剩余均存在显著负相关(r＝-0.394、-0.253，-0.240、-0.192，均有 P＜0.05)；与新生儿 PO2的相关性差异无统计学意义(r＝-0.186、-0.098，均有 P＞ 0.05)。结论急性胎儿窘迫时孕妇血清激活素 A水平明显高于正常孕妇，提示孕妇血清激活素 A的水平变化在产前急性胎儿窘迫的监测中具有重要的临床意义和价值。 |
| 英文摘要: |
| Objective To explore the predictive value of maternal and umbilical cord blood activin A levels in acute fetal distress during labor.Methods From november 2017 to may 2018 totally 121 cases in obstetrics department in Anhui Province Maternaland Children?care Hospital were selected in study.They were divided into the fetal distress group(n＝59)and control group(n＝ 69).Double antibody sandwich ABC?ELISA assay was used to measure the level of activin A in maternal blood and umbilical cordblood as well as umbilical arterial blood gas PH value.The correlation between activin A and fetal distress was analyzed.Results There was no significant difference in gestational age，weight and gender between the study group and the control group(all P＞ 0.05)while the differences in delivery methods were statistically significant(P＜0.05)，Different delivery methods had no signifi? canteffe，ct on maternal activin A(both P＞0.05).The levels of activin A of maternal blood and umbilical cord blood in fetal distress group was(348.62±233.14，35.56±39.80)ng/mL，and that in control group was(34.04±22.75，2.93±3.29)ng/mL，and the levels of activin A of maternal blood and umbilical cord blood were significantly higher in the fetal distress group than the control group(both P＜0.05).In the fetal distress group newborn umbilical artery had significantly lower PH［(7.19±0.11)vs.(7.25±0.06)］， higher base excess［(-5.96±4.42)mmol/L vs.(-4.42±2.78)mmol/L］and higher PCO2［PCO2:(59.25±13.59)mmHg vs.(51.72± |
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