| 李金银,杨威,吕媛媛,等.晚钠电流抑制剂雷诺嗪对犬急性心房电重构的影响[J].安徽医药,2020,24(2):225-228. |
| 晚钠电流抑制剂雷诺嗪对犬急性心房电重构的影响 |
| Effects of late sodium current inhibitor ranolazine on acute atrial electrical remodeling in dogs |
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| DOI：10.3969/j.issn.1009?6469.2020.02.004 |
| 中文关键词: 心房颤动 抗心律失常药 钠通道 犬 心房电重构 雷诺嗪 |
| 英文关键词: Atrial fibrillation Anti?arrhythmia agent Sodium channels Dogs Atrial electrical remodeling Ranolazine |
| 基金项目:湖北省卫生计生委面上项目( WJ2017M172) |
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| 中文摘要: |
| 目的探讨晚钠电流抑制剂对犬急性心房电重构的影响。方法选择性晚钠电流抑制剂雷诺嗪在 24只犬中建立急性心房电重构模型并采用随机数字表法分为低、中、高剂量组，与对照组比较房颤持续时间、心房有效不应期( AERP)、房颤诱发率等变化。结果三个剂量组较对照组的房颤持续时间是下降但差异无统计学意义( F＝1.95，P＝0.154)；与对照组相比，三个剂量组的房颤诱发率均明显下降，差异有统计学意义( χ2＝53.25，P＜0.01)其中低剂量组( 53.4%比 74.3%)中剂量组(41.6%比 74.3%)，高剂量组( 34.0%比 74.3%)。三个剂量组所测的 ERP较对照延长，差异有统计学意义( P＜0)。结论组，.05，雷诺嗪可通过减弱晚钠电流可以明显改善急性心房电重构并抑制房颤的诱发。 |
| 英文摘要: |
| Objective To explore the effects of late sodium current inhibitor，ranolazine on acute atrial electrical remodeling in dogs.Methods Acute atrial electrical remodeling was established in a total of 24 dogs with ranolazine，which were randomly as? signed into the low，medium and high dose groups and were compared with the control group in duration of atrial fibrillation，atrial effective refractory period(AERP)，and atrial fibrillation induction rate.Results Compared with the control group，the duration of atrial fibrillation in the three dose groups was decreased，but there was no significant difference(F＝1.95，P＝0.154)，meanwhile， the induction rate of atrial fibrillation in the three dose groups was significantly decreased and there was significant difference(low dose group:53.4% vs. 74.3%；medium dose group:41.6% vs. 74.3%；high dose group:34.0% vs. 74.3%；χ2＝53.25，P＜0.01).The ERP of the three dose groups was longer than that of the control group(P＜0.05).Conclusion Ranolazine can significantly im?prove acute atrial electrical remodeling and inhibit the induction of atrial fibrillation by reducing late sodium current. |
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