| 贾长河,谢毅,袁媛,等.微管相关蛋白样激酶 1在胃癌组织中的表达及其临床意义[J].安徽医药,2020,24(2):271-275. |
| 微管相关蛋白样激酶 1在胃癌组织中的表达及其临床意义 |
| Expression and clinical pathological significance of doublecortin?like kinase 1 in gastric cancer tissue |
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| DOI：10.3969/j.issn.1009?6469.2020.02.015 |
| 中文关键词: 胃肿瘤 微管相关蛋白质类 免疫组织化学 预后 转移 |
| 英文关键词: Stomach neoplasms Microtubule?associated proteins Immunohistochemistry Prognosis Metastasis |
| 基金项目:河南省科学技术厅科技发展计划项目( 162102310275) |
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| 摘要点击次数: 1898 |
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| 中文摘要: |
| 目的研究微管相关蛋白样激酶 1(doublecortin?like kinase 1，DCLK1)在胃癌组织中的表达及其临床意义。方法回顾性分析 2006年 5月至 2011年 7月在河南省人民医院住院治疗的 267例胃癌病人临床病理资料，免疫组化染色法检测 267例胃癌组织和 138例癌旁正常组织中 DCLK1的表达，分析 DCLK1表达与胃癌病人临床病理特征之间的关系， Cox风险回归模型回归分析影响胃癌病人预后生存的影响因素， Kaplan?Meier法绘制不同 DCLK1表达水平病人的 5年总体生存和无复发生存曲线， Log?rank法比较 5年总体生存和无复发生存的差异。结果 DCLK1在胃癌组织中的高表达率 71.9%(192/267)高于癌旁正常组织 26.1%(36/138)。单因素分析显示 DCLK1高表达与病人性别、年龄，肿瘤大小，位置等临床病理因素之间无显著关联(P＞0.05)与肿瘤分化程度、浸润深度、神经侵犯、脉管侵犯、淋巴转移及临床分期等临床病理因素之间有关( P＜0.05)。 Cox回归分析显示，DCLK1高表达、临床分期和肿瘤分化程度是胃癌病人总生存率和无复发生存率的独立影响因素( P＜0.05)。 Kaplan?Meier生存分析显示， DCLK1高表达的胃癌病人的总生存率和无复发生存率较低( P＜0.05)。结论 DCLK1在胃癌组织中高表达是胃癌病人预后生存的独立影响因素。 |
| 英文摘要: |
| Objective To investigate the expression and clinical pathological significance of doublecortin?like kinase 1(DCLK1) in gastric cancer tissues.Methods Clinical pathological data of 267 patients with gastric cancers hospitalized from May 2006 toJuly 2011 were retrospectively reviewed.Expression of DCLK1 in gastric cancer tissues and adjacent normal tissues from 267 casesand 138 cases respectively was determined by immnunohistochemistry.The relationship between DCLK1 expression and clinicalpahtological parameters was analyzed.Cox analysis was performed to analyze the independent prognostic factors of patients with gas?tric cancer.The 5?year overall survival and recurrence?free survival curves of patients with different DCLK1 expression levels weredrawn by Kaplan?Meier method and the 5?year overall survival and recurrence?free rates were compared by Log?rank method.Re? sults The high expression rate of DCLK1 in gastric cancer tissues was 71.9%(192/267)，which was higher than that in adjacent normal tissues 26.1%(36/138).High expression of DCLK1 in gastric cancer tissues did not correlate with gender，age，tumor size and site(P＞0.05).High expression of DCLK1 statistically significantly correlated with tumor differentiation，depth of invasion， nerve infiltration，venous infiltration，lymph nodal metastasis and clinical stage(P＜0.05).Cox analysis indicated that DCLK1 high expression，clinical stage and tumor differentiation were independent factors in the overall survival rate and recurrence?free survivalrate of gastric cancer patients(P＜0.05).Kaplan?Meier survival analysis showed that the overall survival rate and recurrence?freesurvival rate of patients with gastric cancer with high DCLK1 expression were lower(P＜0.05).Conclusion DCLK1 high expres? sion is an independent prognostic factor of gastric cancer patients. |
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