文章摘要
陈竹雨.导管相关性血流感染儿童血清降钙素原水平研究[J].安徽医药,2020,24(2):320-322.
导管相关性血流感染儿童血清降钙素原水平研究
Level research of procalcitonin in children with catheter?related bloodstream infection
  
DOI:10.3969/j.issn.1009?6469.2020.02.027
中文关键词: 导管相关性感染/诊断  感染  C反应蛋白质  降钙素  白细胞计数  血流感染  儿童
英文关键词: Catheter?related infections/diagnosis  Infection  C?reactive protein  Calcitonin  Leukocyte count  Blood? stream infection  Child
基金项目:张家口市科学技术研究与发展计划项目(1521029D)
作者单位
陈竹雨 张家口市第一医院检验科河北张家口 075000 
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中文摘要:
      目的分析血清中降钙素原( PCT)在儿童导管相关性血流感染( CRBSI)中的潜在诊断意义。方法选取 2017年 3月至 2018年 5月张家口市第一医院收治的留置中心静脉导管儿童以及健康体检儿童为研究对象,根据临床医师诊断分为观察组、对照组和健康组,测量其 PCT水平和其他血清标志物水平,并分析 CRBSI儿童的病原菌感染情况。结果纳入研究的 153例留置中心静脉导管的儿童中, 38例诊断为 CRBSI,发病率为 24.8%;CRBSI病儿 PCT水平明显高于对照组( t=2.62,P=0.018)和健康组( t=3.13,P=0.009); CRBSI病儿 CRP水平和 WBC水平高于健康组( t=2.55,P=0.027;t=2.19,P=0.036)但与对照组相比差异无统计学意义( t=1.65,P=0.058;t=1.51,P=0.077); 38例 CRBSI病儿中 19例( 50%)为革兰阳性菌感,染, 15例(39.5%)为革兰阴性菌感染,剩余 4例( 10.5%)为真菌感染。且革兰阴性菌感染的 CRBSI病儿 PCT水平明显高于革兰阳性菌感染者( t=2.57,P=0.023)C反应蛋白( CRP)含量与 PCT水平变化一致, WBC水平也存在相同趋势,但组间差异无统计学意义。结论 PCT水平变化监测可,能对儿童 CRBSI的诊断及感染病原体的鉴别有益。
英文摘要:
      Objective To discuss the diagnostic significance of serum procalcitonin(PCT)in catheter?related bloodstream infec? tion(CRBSI)of children.Methods Between March 2017 to May 2018,the children in The First Hospital of Zhangjiakou were se? lected as research objects,and divided into observation group,control group and healthy control group,PCT and other serum mark? er level were measured,and analyzed the pathogen infection status of CRBSI children.Results 153 children used central venous catheter were included in this research,38 cases diagnosed with CRBSI(24.8%); PCT level in CRBSI children were significantly higher than the control group(t=2.62,P=0.018)and healthy control group(t=3.13,P=0.009); CRP and WBC level in CRBSI children were higher than healthy control group(t=2.55,P=0.027;t=2.19,P=0.036),but had no statistical difference compared with control group(t=1.65,P=0.058;t=1.51,P=0.077); 19 cases(50%) were gram ? positive bacteria infection,15 cases(39.5%)were gram?negative bacteria infection,4 cases(10.5%)were fungal infection.And PCT level in CRBSI children with gram?negative bacteria infection was significantly higher than gram?positive bacterium infection(t=2.57,P=0.023),the change of CRP level consistent with PCT,the WBC level also had the same trend,but there was no statistically significant difference between the groups.Conclusion Monitoring the change of PCT on children may be good for the diagnosis of CRBSI and the differential diagno?sis of infection pathogens.
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