| 樊冬杰,黄玉伟.铝碳酸镁联合四联疗法治疗幽门螺杆菌感染并十二指肠溃疡 120例临床观察[J].安徽医药,2020,24(2):393-397. |
| 铝碳酸镁联合四联疗法治疗幽门螺杆菌感染并十二指肠溃疡 120例临床观察 |
| Clinical observation of hydrotalcite combined with quadruple therapy in the treatment of Hp infection with DU |
| |
| DOI：10.3969/j.issn.1009?6469.2020.02.047 |
| 中文关键词: 十二指肠溃疡 药物疗法，联合 幽门螺杆菌 奥美拉唑 阿莫西林 克拉霉素 铋 铝碳酸镁 幽门螺杆菌根治 |
| 英文关键词: Duodenal ulcer Drug therapy,combination Helicobacter pylori Omeprazole Amoxicillin Clarithromycin Bismuth Hydrotalcite Radical treatment of helicobacter pylori |
| 基金项目: |
|
| 摘要点击次数: 2669 |
| 全文下载次数: 734 |
| 中文摘要: |
| 目的探讨铝碳酸镁联合幽门螺杆菌( Hp)根治对 Hp感染并十二指肠溃疡(DU)病人胃窦炎症程度、炎症介质、胃肠激素水平等和环氧化酶 ?2(Cox?2)的影响。方法选取 2014年 8月至 2017年 2月上海市第一人民医院宝山分院接诊的 240例 Hp感染并 DU病人采用随机数字表法分为观察组( 120例)和对照组( 120例)对照组给予奥美拉唑、阿莫西林、克拉霉素、胶体果胶铋四联根治治疗，观察组加用铝碳酸镁，均治疗 4周，比较两组临床疗效、 H，p根除率、胃窦炎症程度及溃疡面积，采用放射免疫法测定血浆和胃窦黏膜组织生长抑素( SST)、促胃液素 ?17(Gas?17)水平，采用酶联免疫检测法测定胃窦黏膜匀浆液中热休克蛋白( HSP 60)、肿瘤坏死因子 ?α(TNF?α)、可溶性血管细胞黏附分子 ?1(VCAM?1)、白细胞介素 ?6(IL?6)及血清 Cox?2水平。结果观察组临床疗效 94.17%优于对照组 80.83%(P＜0.05)，观察组和对照组治疗后 Hp根除率比较，差异无统计学意义(85.83%比 78.33%，P＞0.05)；两组病人胃窦黏膜组织的慢性炎症、活动性炎症程度均低于治疗前( P＜0.05)，且观察组慢性炎症、活动性炎症程度明显低于对照组( P＜0.05)；两组 DU病人治疗后溃疡面积均低于治疗前( P＜0.05)观察组溃疡面积缩小幅度大于对照组(P＜0.05)；观察组治疗后血浆胃泌素 Gas?17、胃窦黏膜组织 Gas?17、血清 Cox?2水平均低于治，疗前和对照组(P＜0.05)；观察组治疗后 TNF?α、IL?6、HSP 60、VCAM?1水平显著低于治疗前和对照组( P＜0.05)。结论铝碳酸镁、奥美拉唑、阿莫西林、克拉霉素、胶体果胶铋五联疗法可有效改善 Hp感染并 DU病人的胃窦炎症程度，减少炎症介质的释放，还能调节胃肠激素和血清 Cox?2水平，治疗效果较好。 |
| 英文摘要: |
| Objective To investigate the effect of hydrotalcite combined with Helicobacter pylori(Hp)eradication on the degree of antral gastritis，inflammatory mediators，levels of gastrointestinal hormones and cyclooxygenase?2(Cox?2)in patients with Hp infec? tion and duodenal ulcer(DU).Methods 240 patients with Hp infection and DU who were treated in the gastroenterology depart?ment of Baoshan District Branch of Shanghai First People’s Hospital from Aug. 2014 to Feb. 2017 were randomly divided into the observation group(120 cases)and the control group(120 cases).The control group was given quadruple eradication of omeprazole， amoxicillin，clarithromycin and colloidal bismuth pectin，and the observation group was additionally given hydrotalcite.Clinical effi? cacy，Hp eradication，degree of antral gastritis and ulcer area were compared between the two groups.The levels of somatostatin(SST)and gastrin?17(Gas?17)in plasma and antral mucosa were determined by radioimmunoassay.The levels of heat shock pro? tein(HSP 60)tumor necrosis factor?α(TNF?α)soluble vascular cell adhesion molecule?1(VCAM?1)，interleukin?6(IL?6)and serumCox?2ing，astricantrummucosahomogenatew，ere determined by enzyme?linked immunosorbent assay.Results The clinical efficacy in the observation group was better than that in the control group(94.17% vs. 80.83%，P＜0.05)，and there was no signifi? cant difference in the eradication rate of Hp between the two groups(85.83% vs. 78.33%，P＞0.05).The degrees of chronic inflam?mation and active inflammation of gastric antral mucosal tissues in two groups were lower than those before treatment(P＜0.05)， and the degrees of chronic inflammation and active inflammation in the observation group were significantly lower than those in thecontrol group(P＜ 0.05).The ulcer area of DU patients after treatment in the two groups was lower than that before treatment(P＜ |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
