文章摘要
肖艳波,张琳,李群,等.血清尿激酶型纤溶酶原激活剂、环氧合酶 2在口腔鳞状细胞癌中的表达及意义[J].安徽医药,2020,24(3):481-484.
血清尿激酶型纤溶酶原激活剂、环氧合酶 2在口腔鳞状细胞癌中的表达及意义
The expression and significance of serum urokinase?type plasminogen activator and cyclooxygenase 2 in oral squamous cell carcinoma
  
DOI:10.3969/j.issn.1009?6469.2020.03.015
中文关键词: 口腔肿瘤  肿瘤,鳞状细胞  尿激酶型纤溶酶原激活剂  环氧化酶 2  淋巴转移
英文关键词: Mouth neoplasms  Neoplasms,squamous cell  Urokinase ? type plasminogen activator  Cyclooxygenase 2  Lymphatic metastasis
基金项目:
作者单位
肖艳波 湖南中医药大学第一附属医院口腔科湖南长沙 410000 
张琳 湖南中医药大学第一附属医院口腔科湖南长沙 410000 
李群 湖南中医药大学第一附属医院口腔科湖南长沙 410000 
左巧娟 湖南中医药大学第一附属医院口腔科湖南长沙 410000 
王宗康 湖南中医药大学第一附属医院口腔科湖南长沙 410000 
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中文摘要:
      目的探讨血清尿激酶型纤溶酶原激活剂( uPA)、环氧合酶 2(COX?2)对口腔鳞状细胞癌( OSCC)病人病情发生发展的影响。方法选取 2017年 2—12月湖南中医药大学第一附属医院确诊的 OSCC病人 90例( OSCC组)健康体检志愿者 90例作为对照组,检测两组研究对象的血清 uPA、COX?2水平,按照不同病理学分级、不同临床分期、是否发生,淋巴结转移 OSCC病人中的血清 uPA、COX?2水平差异。结果 OSCC组病人血清 uPA、COX?2水平[(5.44±2.71)mg/L、(27.8±9.3)IU/L]显著的高于对照组[(1.39±0.48)mg/L、(6.5±2.3)IU/L]均差异有统计学意义( t=13.960、21.092,P<0.05);临床分期( Ⅲ期+Ⅳ期)、发生淋巴结转移的 OSCC组病人血清 uPA水平[(7.0,6±2.26)mg/L、(6.49±2.28)mg/L]显著的高于临床分期( Ⅰ期+Ⅱ期)、未发生淋巴结转移的 OSCC组病人[(4.20±2.56)mg/L、(4.67±2.55)mg/L]均差异有统计学意义( t=-5.365、3.525,P<0.05);在不同病理学分化的 OSCC病人中,血清 uPA水平差异无统计学意义( t=-0.8,31,P>0.05);临床分期( Ⅲ期+Ⅳ期)、发生淋巴结转移、低分化的 OSCC组病人血清 COX?2水平[(32.5±8.4)IU/L、(33.0±7.3)IU/L、(34.6±8.7)IU/L]显著的高于临床分期( Ⅰ期+Ⅱ期)、未发生淋巴结转移及高中分化的的 OSCC组病人[(24.1±7.6)IU/L、(23.2±8.8)IU/L、(23.8±9.0)IU/L]均差异有统计学意义( t=-4.885、5.655、 -5.756,P<0.05)。结论 OSCC组病人血清 uPA、COX?2水平较健康对象显著升高,可能,对 OSCC的侵袭转移起促进作用。
英文摘要:
      Objective To investigate effect of serum urokinase?type plasminogen activator(uPA)and cyclooxygenase 2(COX?2) expression levels in the development of oral squamous cell carcinoma(OSCC)patients.Methods A total of 90 patients with OS?CC diagnosed in The First Affiliated Hospital of Hunan University of Chinese Medicine from February 2017 to December 2017(OSCC group)and 90 healthy volunteers(control group)were selected.The serum levels of uPA and COX?2 were measured in the two groups.Differences in the serum uPA and COX?2 levels in the patients with OSCC who had pathological grades,different clini? cal stages,and whether or not lymph node metastasis occurred.Results The serum levels of uPA and COX?2 in the OSCC group[(5.44±2.71)mg/L,(27.8±9.3)IU/L]were significantly higher than those in the control group[(1.39±0.48)mg/L,(6.5±2.3)IU/L](The t values are:13.960,21.092,P<0.05).The clinical stage(stage III+IV)and the OSCC group with lymph node metastasis had significant higher serum uPA levels[( 7.06±2.26)mg/L,(6.49±2.28)mg/L]than patients at clinical stage(stage I+II)and OSCC patients with no lymph node metastasis[(4.20±2.56)mg/L,(4.67±2.55mg/L).The difference was statistically significant(The t val? ues are:-5.365,3.525,P<0.05).In different pathologically differentiated OSCC patients,serum uPA levels was with no statistical significance(t=-0.831,P>0.05).The serum COX?2 level of clinical stage(stage III+IV),lymph node metastasis,poorly differentiat? ed OSCC group[(32.5±8.4)IU/L,(33.0±7.3)IU/L,(34.6±8.7)IU/L]was significantly higher than the clinical stage(stage Ⅰ+Ⅱ) and the patients with lymph node metastasis and high?differentiation OSCC[( 24.1±7.6)IU/L,(23.2±8.8)IU/L,(23.8±9.0)IU/L]. The difference was statistically significant(The t values are:-4.885,5.655,-5.756,P<0.05).Conclusions The serum levels of uPA and COX?2 in the OSCC group were significantly higher than those in healthy subjects,which may promote the invasion and metastasis of OSCC.
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