| 卜寒莉,陆召军,高修银,等.代谢综合征与急性脑梗死病人早期神经功能损伤的相关性[J].安徽医药,2020,24(4):735-738. |
| 代谢综合征与急性脑梗死病人早期神经功能损伤的相关性 |
| Correlation between metabolic syndrome and early neurological impairment in patients with acute cerebral infarction |
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| DOI：10.3969/j.issn.1009?6469.2020.04.025 |
| 中文关键词: 脑梗死 代谢综合征 X 高血糖症 高血压 高甘油三酯血症 胆固醇， HD 腰围 半胱氨酸 因果律 神经功能损伤 |
| 英文关键词: Brain infarction Metabolic syndrome X Hyperglycemia Hypertension Hypertriglyceridemia Cholesterol, HDL Waist circumference Cysteine Causality Neurological impairment |
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| 中文摘要: |
| 目的研究代谢综合征( MS)与急性脑梗死( ACI)病人早期神经功能损伤的相关性并探讨相关机制。方法分析 2018年 4—12月徐州医科大学附属医院收治的 518例 ACI病人临床资料，分为 MS组( n＝205)和非 MS组( n＝313)采用美国国立卫生研究院卒中量表( NIHSS)评估 ACI病人早期神经功能损伤情况。研究 MS组分及组分个数对早期神经功能，损伤程度的影响。结果 MS组病人高血糖比例、高血压比例、腰围( WC)、三酰甘油( TG)、空腹血糖( FBG)、同型半胱氨酸( HCY)、 NIHSS评分均高于非 MS组［ 73.7%比 24.0%、76.1%比 41.9%、(90.52±6.64)cm比( 84.17±6.80)cm、(2.21±1.35)mmol/L比( 1.43±0.98) mmol/L、(7.22±2.79)mmol/L比( 5.85±2.14)mmol/L、(18.15±8.97)umol/L比( 14.18±8.78)umol/L、(8.32±6.09)分比( 5.35±4.23)分］高密度脂蛋白胆固醇( HDL?C)水平低于非 MS组［(1.03±0.24)mmol/L比( 1.26±0.31)mmol/L］(均 P＜0.05)。早期神经功能损伤情，况与年龄( rs＝0.135)、 WC(rs＝0.373)、高血糖( rs＝0.133)、 MS(rs＝1.195)、 MS组分个数( rs＝0.179)、 MS组中 MS组分个数( rs＝0.222)均呈正相关； MS组分个数不同，病人神经功能缺损程度差异有统计学意义( P＜0.05)MS?0组与 MS?5组、 MS?1组与 MS?5组、 MS?2组与 MS?5组、 MS?3组与 MS?5组神经功能损伤程度差异有统计学意义( P＜0.05)。结论，MS组分及组分个数与早期神经功能损伤程度呈正相关；随着 MS组分个数的增加， ACI病人出现重度神经功能损伤的可能性大。 |
| 英文摘要: |
| Objective To investigate the relationship between metabolic syndrome(MS)and the early neurological impairment in patients with acute cerebral infarction(ACI)and to explore its related mechanisms.Methods A total of 518 patients with ACI ad?mitted to the Affiliated Hospital of Xuzhou Medical University from April to December of 2018 were assigned into MS group(n＝ 205)and non?MS group(n＝313).The National Institute of Health Stroke Scale(NIHSS)was used to assess the degree of early neu?rological impairment.The effect of MS components and the number of components on the degree of early neurological impairmentwas studied.Results The proportion of hyperglycemia and hypertension，waist circumference(WC)triglyceride(TG)，fasting blood glucose(FBG)，homocysteine(HCY)andNIHSSscorewerehigherandthehigh?densitylipoproteinc，holesterol level(HDL?C)was lower in MS group than non?MS group［73.7% vs. 24.0%，76.1% vs. 41.9%，(90.52±6.64)cm vs.(84.17±6.80)cm，(2.21±1.35) mmol/L vs.(1.43±0.98)mmol/L，(7.22±2.79)mmol/L vs.(5.85±2.14)mmol/L，(18.15±8.97)umol/L vs.(14.18±8.78)umol/L，(8.32± 6.09)vs.(5.35±4.23)，(1.03±0.24)mmol/L vs.(1.26±0.31)mmol/L］； differences showed statistically significance(all P＜0.05). Early neurological impairment was positively correlated with age(rs＝0.135)，WC(rs＝0.373)，hyperglycemia(rs＝0.133)，MS(rs＝1.195)，number of MS components(rs＝0.179)，number of MS components in the MS group(rs＝0.222).With the different number of MS components，the degrees of neurological impairment in patients showed statistically significant difference(P＜0.05).There were differences in the degree of neurological damage between MS?0 group and MS?5 group，MS?1 group and MS?5 group，MS?2 group and MS?5 group，MS?3 group and MS?5 group(P＜0.05).Conclusions MS components and the number of MS componentsare positively correlated with the degree of early neurological impairment.ACI patients have a high possibility of severe neurologicalimpairment with the increase of the number of MS components. |
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