| 赵璐,杜小明.血管内皮生长因子和性别决定区 Y框蛋白 2在胃癌中的表达及与预后的关系[J].安徽医药,2020,24(4):746-750. |
| 血管内皮生长因子和性别决定区 Y框蛋白 2在胃癌中的表达及与预后的关系 |
| Expression and prognostic significance of VEGF and SOX2 in gastric cancer |
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| DOI：10.3969/j.issn.1009?6469.2020.04.028 |
| 中文关键词: 胃肿瘤 血管内皮生长因子类 性别决定区 Y框蛋白 2 预后 |
| 英文关键词: Stomach neoplasms Vascular endothelial growth factors Sexdeterminingregion Y?box2 Prognosis |
| 基金项目:蚌埠医学院自然科学基金( BYKY17190) |
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| 中文摘要: |
| 目的探讨血管内皮生长因子( vascular endothelial growth factor，VEGF)和性别决定区 Y框蛋白 2(SOX2)在胃癌组织中的表达及其与临床病理和预后的意义。方法收集 2012年 3月至 2017年 12月皖北煤电集团总医院病理科存档的胃癌手术标本 40例，应用免疫组化检测 40例胃癌和 32例癌旁组织中 VEGF和 SOX2的表达情况，观察胃癌病人 VEGF和 SOX2的表达情况并分析与不同病理特征和生存的相关性。结果 ①胃癌组织中 VEGF与 SOX2的表达率分别为 70.0%及 65.0%，癌旁组织中分别是 46.4%及37.5%，均差异有统计学意义(P＜0.05)。②VEGF的高表达与胃癌病人低分化、局部更深浸润、出现淋巴结转移及高临床分期有关(P＜0.05)SOX2的高表达与胃癌病人出现淋巴结转移及高临床分期有关( P＜0.05)。 ③Spearman相关性分析发现，在胃癌中 VEGF的表达，与 SOX2的表达呈正相关关系( r＝0.375，P＝0.017)。生存分析显示胃癌病人中 VEGF及 SOX2同时高表达与 VEGF或 SOX2单独高表达或不表达相比具有较差的预后( P＜0.05)。结论 VEGF和 SOX2的高表达水平可能促进胃癌的发生、发展和侵袭，并且预示着病人有着更差的预后，有望成为胃癌诊断、治疗和预后判断的一个靶标。 |
| 英文摘要: |
| Objective To explore the expressions of vascular endothelial growth factor(VEGF) and sex?determining region Y(SRY)?related HMG box 2(SOX2)in gastric cancer as well as its clinicopathologic and prognostic significance.Methods Fortyspecimens of gastric cancer filed in the Department of Pathology，General Hospital of Wanbei Coal and Electricity Group from March 2012 to December 2017 were collected and the expressions of VEGF and SOX2 weredetected in 40 cases of gastric cancer and 32 cases of para?carcinoma tissues.The expressions of VEGF and SOX2 in gastric cancer patients with various pathological characteristics and survival were observed and the correlation between them was analyzed.Results The expression rates of VEGF and SOX2 in gastric cancer tissues were 70.0% and 65.0%，respectively，and 46.4% and 37.5% in para?carcinoma tissue，respec? tively；differences were found statistically significant(P＜0.05).The high expression of VEGF was associated with low differentia?tion，deeper local immersion，lymph node metastasis and high TNM stage in patients with gastric cancer(P＜0.05)and the high expression of SOX2 was associated with lymph node metastasis and high TNM stage in patients with gastric cancer(，P＜0.05).Spearman correlation analysis found that the expression of VEGF in gastric cancer was positively correlated with SOX2 expression(r＝0.375，P＝0.017).Survival analysis showed that both high expressions of VEGF and SOX2 in patients with gastric cancer hada poorer prognosis compared with high expressions or non?expression of VEGF or SOX2 alone(P＜0.05).Conclusion HighVEGF and SOX2 expression levels may promote the formation，development and invasion of gastric cancer and indicate a poorer prognosis，which may become biomarkers for the diagnosis，treatment and prognostic evaluation of gastric cancer. |
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