| 代宇,叶勇,林影,等.微生态制剂对重症急性胰腺炎病人的炎症指标、降钙素原、尿胰蛋白酶原激活肽水平及肠道菌群的影响研究[J].安徽医药,2020,24(4):826-830. |
| 微生态制剂对重症急性胰腺炎病人的炎症指标、降钙素原、尿胰蛋白酶原激活肽水平及肠道菌群的影响研究 |
| Effects of microecologicals on inflammatory index，PCT，TAP levels and intestinal flora of patients with severe acute pancreatitis |
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| DOI：10.3969/j.issn.1009?6469.2020.04.047 |
| 中文关键词: 胰腺炎，急性坏死性 肠道营养 肿瘤坏死因子 α 白细胞介素 6 白细胞介素 8 肠杆菌属 肠球菌属 微生态制剂 降钙素原 尿胰蛋白酶原激活肽 肠道菌群 |
| 英文关键词: Pancreatitis,acute necrotizing Enteral nutrition Tumor necrosis factor?alpha Interleukin?6 Interleukin?8 Enterobacter Enterococcus Microecologicals Procalcitonin Urinary trypsinogen activating peptide Intestinal flora |
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| 目的探究微生态制剂对重症急性胰腺炎( SAP)病人的炎症指标、降钙素原( PCT)、尿胰蛋白酶原激活肽( TAP)水平及肠道菌群的影响，为病人治疗提供临床指导。方法回顾性分析 2016年 10月至 2018年 8月在内江市第二人民医院就诊的 112例 SAP病人的诊疗情况。根据治疗方案不同，分为研究组( 60例)和对照组( 52例)对照组病人给予肠内营养治疗，研究组病人在肠内营养基础上给予微生态制剂治疗，两组治疗疗程均为 7d。分析比较两组病人，临床疗效，比较两组病人治疗前后急性生理与慢性健康评分( APACHEⅡ评分)、炎性因子、 PCT、TAP水平及肠道菌群情况。结果研究组临床治疗有效率(88.33%)明显高于对照组( 73.08%)差异有统计学意义( P＜0.05)。治疗后，两组 APACHEⅡ评分均明显降低，且研究组 APACHEⅡ评分( 7.25±3.49)明显低于对，照组( 8.92±3.60)(P＜0.05)。治疗后，两组病人血清肿瘤坏死因子 α(TNF?α)、白介素 6(IL?6)、白介素 8(IL?8)、 PCT、TAP水平明显下降( P＜0.05)且研究组病人血清 TNF?α、IL?6、IL?8、PCT、TAP水平明显低于对照组( P＜0.05)。治疗后，研究组病人肠道双歧杆菌、乳杆菌计数，明显高于对照组( P＜0.05)，肠杆菌、肠球菌计数明显低于对照组( P＜0.05)。结论微生态制剂治疗 SAP病人疗效确切，可明显降低病人炎性因子和 PCT、TAP水平，调节肠道菌群微生态平衡，值得临床应用。 |
| 英文摘要: |
| Objective To investigate the effects of microecologicals on inflammatory index，procalcitonin(PCT)，urinary trypsino? gen activates peptides(TAP)levels and intestinal flora of patients with severe acute pancreatitis(SAP)，in order to provide clini? cal guidance for the treatment of patients.Methods The clinical data of 112 cases of patients with SAP who received treatment in NeiJiang Second People’s Hospital from October 2016 to August 2018 were retrospective analyzed.Patients were assigned into study group(52 cases)and control group(60 cases)according to different treatment methods.Patients in the control group were treated with enteral nutrition therapy，while patients in the study group were treated with microecologicals on the basis of enteral nu?trition therapy.The treatment duration of both groups was 7 d.The clinical curative effect，the acute physiology and chronic health evaluation Ⅱ score(APACHE Ⅱ score)，inflammatory factors，PCT and TAP levels，intestinal flora before and after treatment in the two groups were analyzed and compared.Results The clinical treatment efficiency of the study group(88.33%)was signifi? cantly higher than 73.08% of the control group，the difference with statistical significance(P＜0.05).After treatment，the APACHE Ⅱ score of the study group and the control group were significantly lower than before treatment(P＜0.05)，and APACHE Ⅱ score of the study group(7.25±3.49)was significantly lower than(8.92±3.60)of the control group，the difference with statistical signifi? cance(P＜0.05).After treatment，the levels of serum tumor necrosis factor α(TNF?α)interleukin?6(IL?6)，interleukin?8(IL?8)PCT，TAP of the two groups were both lower than those before treatment(P＜0.05)，and，the levels of the TNF?α，IL?6，IL?8，PCT，，TAP of the study group were lower than those of the control group(P＜0.05).After treatment，the intestinal bifidobacteria and lacto? bacillus count of the study group were significantly higher than those of the control group(P＜0.05)，and enterobacter and entero? coccus count of the study group were significantly lower than those of the control group(P＜0.05).Conclusion Microecologicalscan be effective treatment of SAP，which can significantly reduce the levels of inflammatory factors，PCT and TAP in patients，and regulate the microecological balance of intestinal flora.It is worthy of clinical promotion. |
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