| 郭英,谭秋红,黄丽.卡马西平致药物超敏反应综合征 2例与文献复习[J].安徽医药,2020,24(4):842-845. |
| 卡马西平致药物超敏反应综合征 2例与文献复习 |
| Carbamazepine?induced drug hypersensitivity syndrome: a report of 2 cases and literature review |
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| DOI：10.3969/j.issn.1009?6469.2020.04.051 |
| 中文关键词: 卡马西平/副作用 疹 药物过敏 地塞米松 癫痫 文献复习 |
| 英文关键词: Carbamazepine/adverse effects Exanthema Drug hypersensitivity Dexamethasone Epilepsy Literature review |
| 基金项目: |
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| 摘要点击次数: 2026 |
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| 中文摘要: |
| 目的探讨卡马西平致药物超敏反应综合征( drug induced hypersensitivity syndrome，DIHS)的临床特点。方法回顾分析株洲市中心医院 2例卡马西平致 DIHS病例，结合文献对卡马西平致 DIHS的临床表现、发病机制以及预防、治疗进行分析。结果 2例病人因治疗癫痫或预防癫痫服用卡马西平片 0.2 g，1天 3次；用药 2～3周出现 DIHS。2例病人均予糖皮质激素治疗，病例 1单用糖皮质激素即缓解，病例 2联用糖皮质激素和人免疫球蛋白治疗后病情缓解。 2例 DIHS病情严重程度不同，糖皮质激素治疗疗程不同。结论卡马西平致 DIHS临床表现多样；早期大剂量糖皮质激素治疗可有效控制症状，病情缓解后糖皮质激素减量应缓慢，并警惕复发。 |
| 英文摘要: |
| Objective To explore the clinical features of drug?induced hypersensitivity syndrome(DIHS)triggered by carbamaze? pine.Methods We retrospectively analyzed 2 patients with DIHS triggered by carbamazepine in Zhuzhou Central Hospital and an?alyzed its clinical manifestations，pathogenesis，prevention and treatment.Results The two patients developed DIHS(0.2 g，three times a day)2 to 3 weeks after taking carbamazepine for the treatment of epilepsy or prevention of epilepsy.Both patients weretreated with glucocorticoids，case 1 relieved with glucocorticoids alone，and case 2 relieved with a combination of glucocorticoids and human immunoglobulin.Two cases of DIHS had different severity，and the courses of treatment with glucocorticoids for the two cases were also different.Conclusions The clinical manifestations of DIHS triggered by carbamazepine are diverse.Early high?doseglucocorticoid therapy can effectively control the symptoms.The glucocorticoid reduction should be slow after the disease is re?lieved，and the relapse should be on the alert. |
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