| 于海涛,刘秋皖,吴君仓.参附注射液治疗非心源性脑卒中疗效观察及对超敏 C反应蛋白、胱抑素 C的影响[J].安徽医药,2020,24(5):989-992. |
| 参附注射液治疗非心源性脑卒中疗效观察及对超敏 C反应蛋白、胱抑素 C的影响 |
| Clinical effect of Shenfu injection on non?cardiogenic stroke and its effect on hypersensitive C?reactive protein and cystatin C |
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| DOI：10.3969/j.issn.1009?6469.2020.05.036 |
| 中文关键词: 卒中 C反应蛋白质 胱抑素 C 参附注射液 |
| 英文关键词: Stroke C?reactive protein Cystatin C Shenfu injection |
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| 中文摘要: |
| 目的探讨参附注射液治疗非心源性脑卒中临床疗效和其对血清超敏 C反应蛋白( hs?CRP)及胱抑素 C(CysC)的影响。方法选取 2018年 1月至 2019年 2月合肥市第二人民医院非心源性脑卒中病人 130例，采用随机数字表法分为对照组( 68例)和观察组( 62例)。比较两组治疗前后血清 hs?CRP、CysC水平以及美国国立卫生研究院卒中量表( NIHSS)评分、日常生活活动能力量表( Barthel指数)和治疗后 90 d临床转归良好率。结果 ①hs?CRP和 CysC与 NIHSS评分呈正相关( R值分别为 0.642、0.315)； ②治疗后观察组 NIHSS评分［(7.74±3.38)比( 9.34±4.89)分］、 Barthel指数评分［(72.50±9.80)比( 65.50±9.99)分］及治疗后 90 d临床转归良好率(79.03%比 61.76%)改善均优于对照组( P＜0.05)； ③治疗后观察组血清 hs?CRP［(4.02±3.27)比( 7.71±6.40)mg/L］及 CysC［(0.93±0.31)比( 1.88±1.01)mg/L］水平均明显低于对照组( P＜0.05)。结论参附注射液能够显著改善非心源性脑卒中病人的神经功能缺失及临床预后，降低血清 hs?CRP、CysC水平。 |
| 英文摘要: |
| Objective To observe the clinical effect of Shenfu injection in patient with non?cardiogenic stroke and the effect on se? rum hypersensitive C?reactive protein(hs?CRP)and cystatin C(CysC).Methods 130 patients with non?cardiogenic stroke wereselected in Second People Hospital of Hefei from January 2018 to February 2019.Correlation analysis of hs?CRP，CysC and NIH Stroke Scale(NIHSS)before and after the treatment were performed.The patients were divided randomly into the control group(68 cases)and the treatment group(62 cases).The NIHSS scores，Barthel index score，modified Rankin revision scale(mRS)scores， serum hs?CRP and CysC levels between the two groups before and after the treatment were compared.Results ① hs?CRP and CysC were positively correlated with NIHSS scores(R values were 0.642，0.315).② The NIHSS score［(7.74±3.38)vs.(9.34± 4.89)］Barthel index score［( 72.50±9.80)vs.(65.50±9.99)］ and good rate of clinical outcome of 90 d after treatment(79.03% vs. 61.76)in the treatment group were better than those in the control group(P＜0.05).③ The serum hs?CRP［( 4.02±3.27)vs.%(7.71±6.40)mg/L］and CysC［(0.93±0.31)vs.(1.88±1.01)mg/L］were significantly lower in the treatment group than the control group(P＜0.05).Conclusion Shenfu injection with significant curative effect on non?cardiogenic stroke can improve neurological deficit and clinical prognosis，reduce serum hs?CRP and CysC levels. |
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