| 任娟,桑学梅,刘艳,等.高强度聚焦超声联合亮丙瑞林治疗子宫腺肌病 30例分析[J].安徽医药,2020,24(7):1381-1384. |
| 高强度聚焦超声联合亮丙瑞林治疗子宫腺肌病 30例分析 |
| Analysis of 30 cases of adenomyosis treated with high?intensity focused ultrasound combined with leuprolide |
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| DOI：10.3969/j.issn.1009?6469.2020.07.028 |
| 中文关键词: 子宫疾病 高强聚焦超声消融 亮丙瑞林 促性腺素释放激素( GnRH?a) 子宫腺肌病 米非司酮 |
| 英文关键词: Uterine diseases High ? intensity focused ultrasound ablation Leuprolide Gonadotropin ? releasing hormone(GnRH?α) Adenomyosis Mifepristone |
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| 中文摘要: |
| 目的分析高强度聚焦超声( High Intensity Focused Ultrasound，HIFU)联合促性腺激素释放激素激动剂( Gonadotropin? Releasing Hormone Agonist，GnRH?α)对子宫腺肌病的治疗及预后影响分析。方法选取 2017年 6月至 2019年 4月在皖北煤电集团总医院行 HIFU治疗的 60例子宫腺肌病病人，采用随机数字表法分为研究组和对照组各 30例，研究组行 HIFU联合亮丙瑞林皮下注射治疗，对照组行 HIFU联合米非司酮口服治疗。分别于治疗前、治疗后第 3个月和第 6个月测定视觉模拟评分(visual analogue scale，VAS)、月经量、血清 CA125水平、血红蛋白含量及子宫体积值。结果两组病人的痛经评分、月经量、子宫体积、血清 CA125水平均较治疗前下降，血红蛋白含量高于治疗前，差异有统计学意义( P＜0.05)。研究组与对照组相比，月经量减少和血红蛋白上升差异无统计学意义( P＞0.05)，但 VAS评分［(4.87±1.01)比( 5.43±0.97)分，(3.63±1.03)比( 4.20±0.93)分］、子宫体积缩小［(159.47±48.23)比( 198.30±51.33)cm3(118.83±34.29)比( 142.63±38.21)cm3］和 CA125水平下降［(53.03± 14.88)比( 62.03±16.14)U/mL，(34.47±10.74)比( 43.03±10.57/mL］均优于对照组，差异有统计学意义( P＜0.05)。在复发率方)U，面，两组比较差异无统计学意义( P＞0.05)，在治疗费用方面，研究组高于对照组。结论 HIFU联合 GnRH?a治疗子宫腺肌病的短期疗效优于 HIFU联合米非司酮治疗，是一种临床值得推广的治疗方案。 |
| 英文摘要: |
| Objective To analyze the effects of high intensity focused ultrasound(HIFU)combined with gonadotropin?releasing hormone agonist(GnRH?α)on the treatment and prognosis of adenomyosis.Methods A total of 60 patients with adenomyosiswere treated with HIFU at the General Hospital of Wanbei Coal and Electricity Group from June 2017 to April 2019 and were di?vided into a study group and a control group with 30 patients in each group by random number table method.The study group re?ceived HIFU combined with GnRH?α，and the control group was treated with HIFU combined with mifepristone.The visual ana? logue scale(VAS)， menstrual volume，serum CA125 level，hemoglobin content and uterine volume values before treatment，at 3 months and 6 months after treatment of the study group and the control group were measured and compared.Results The dysmen? orrhea score，menstrual volume，uterine volume，and serum CA125 levels of both groups after treatment were lower than those be? fore treatment，while hemoglobin content was increased，and the differences were statistically significant(P＜0.05).Compared with the control group，there was no significant difference in the reduction of menstrual flow and the increase of hemoglobin in the study group(P＞0.05)，but the VAS score［( 4.87±1.01)vs.(5.43±0.97)(0.63±1.03)vs.(4.20±0.93)］，uterine volume reduction［( 159.47±48.23) vs.(198.30±51.33)cm3(118.83±34.29) vs.(142.6，3±38.21)cm3］， and CA125 level［( 53.03±14.88) vs.(62.03±16.14)U/mL，(34.47±10.74)vs.(43.03，±10.57)U/mL］were all higher than those of the control group，and the differences were statistically significant(P＜0.05).In terms of recurrence rate，there was no significant difference between the two groups(P＞0.05)，while of treatment costs，the study group was higher than the control group.Conclusion The short?term efficacy of HIFUcombined with GnRH?α in the treatment of adenomyosis is superior to HIFU combined with mifepristone.Therefore，it is a clinically worthwhile treatment plan. |
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