| 吴云华,代前军.超声造影参数对中晚期乳腺癌新辅助化疗有效性的应用价值[J].安徽医药,2020,24(7):1399-1402. |
| 超声造影参数对中晚期乳腺癌新辅助化疗有效性的应用价值 |
| Evaluation of contrast?enhanced ultrasound parameters in the effectiveness of neoadjuvant chemotherapy for advanced breast cancer |
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| DOI：10.3969/j.issn.1009?6469.2020.07.033 |
| 中文关键词: 乳腺肿瘤 超声检查，乳房 放化疗，辅助 有效性 评价 |
| 英文关键词: Breast neoplasms Ultrasonography,mammary Chemoradiotherapy,adjuvant Effectiveness Evaluation |
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| 中文摘要: |
| 目的探讨超声造影参数对中晚期乳腺癌新辅助化疗有效性的评价应用。方法选取 2016年 1月至 2019年 11月安徽省滁州市第一人民医院中晚期乳腺癌病人 50例，所有病人均给予新辅助化疗并于化疗前、化疗 1疗程后行超声造影检查，分析超声造影参数对化疗有效性的评价价值。结果化疗有效者 36例，有效率 72.00%。对比化疗有效者和无效者在使用化学药物治疗前后造影时间 ?强度的上升时间( AT)、达峰时间( TTP)、平均增强时间( MTT)以及化疗无效者的峰值强度( PI)、曲线下面积( AUC)均差异无统计学意义( P＞0.05)；化疗有效者化疗前 PI，AUC数值分别为( 33.56±3.66)DB，(666.21±68.58)DB·s，而化疗后数值降，为( 23.66±2.85)DB，(523.89±51.37)DB·s，数值远低于化疗前；化疗有效者 PI，AUC下降值分别为( 10.05±1.05)DB，(122.36±11.58)DB·s，远远高于无效者，差异有统计学意义( P＜0.05)；新辅助化疗方案对中晚期乳腺癌有效性的敏感度、特异度、准确度中， PI下降值 >9.12 DB时，为 86.11%、71.42%、82.00%；AUC下降值 >110.53 DB·s，为 88.87%、78.57%、84.00%；PI联合 AUC下降值为 94.45%、85.71%、92.00%，PI联合 AUC对比单纯 PI、AUC评估有较高的价值，差异有统计学意义( P＜0.05)。结论超声造影参数对中晚期乳腺癌新辅助化疗有效性有较高的应用价值， PI、AUC可作为评价病人化疗有效性的重要指标，且 PI联合 AUC的评价效能更高。 |
| 英文摘要: |
| Objective To discuss the evaluation of contrast?enhanced ultrasound parameters in the effectiveness of neoadjuvant che?motherapy for advanced breast cancer.Methods Fifty patients with advanced breast cancer admitted to the First People’s Hospitalof Chuzhou from January 2016 to November 2019 were selected.All patients were given neoadjuvant chemotherapy and underwentcontrast?enhanced ultrasonography before and after 1 course of chemotherapy.The value of contrast?enhanced ultrasound parametersin evaluating the effectiveness of chemotherapy was analyzed.Results In this study，chemotherapy is effective for 36 cases，with an effective rate of 72.00%.Comparison of rise time(AT)，peak time(TTP)and mean enhancement time(MTT)before and after che? motherapy between effective and ineffective patients showed no significant differences(P＞0.05).There were no significant differ? ences in the peak intensity(PI)and area under curve(AUC)before and after chemotherapy in patients with no response to che? motherapy(P＞0.05).In patients with effective chemotherapy，the values of PI and AUC were(33.56±3.66)DB and(666.21±68.58) DB·s before chemotherapy，and(23.66±2.85)DB and(523.89±51.37)DB·s after chemotherapy，The PI and AUC decrease values were(10.05±1.05)DB，(122.36±11.58)DB·s，PI and AUC in patients with effective chemotherapy，which were significantly higher than those in patients with no response to chemotherapy.(P＜0.05).in evaluating the efficacy of neoadjuvant chemotherapy for ad?vanced breast cancer were good.When PI decreased more than 9.12DB，the sensitivity，specificity and accuracy of neoadjuvant che? motherapy were 86.11%，71.42%，82.00%，respectively.When AUC decreased more than 110.53 DB·s，the sensitivity，specificityand accuracy of neoadjuvant chemotherapy were 88.87%，78.57%，84.00%，respectively.When evaluated with PI combined AUC de? creased，those were94.45%，85.71%，92.00%，respectively.PI combined with AUC decreased had higher value for assessment than PI and AUC decreased alone.Conclusions Contrast?enhanced ultrasound parameters are related to the effectiveness of neoadju?vant chemotherapy for advanced breast cancer.PI and AUC can be used as important indicators to evaluate the effectiveness of che?motherapy，and PI combined with AUC has higher evaluation efficiency. |
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