| 徐升,张念志,徐经世.益气化痰祛瘀方对慢性阻塞性肺病急性加重期血清同型半胱氨酸、组织纤溶酶原激活物、纤溶酶原激活物抑制物?1水平的影响[J].安徽医药,2020,24(7):1440-1443. |
| 益气化痰祛瘀方对慢性阻塞性肺病急性加重期血清同型半胱氨酸、组织纤溶酶原激活物、纤溶酶原激活物抑制物?1水平的影响 |
| Effect of Yiqi Huatan Quyu Recipe on Hcy，t?PA and PAI?1 levels in patients with acute exacerbation of COPD |
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| DOI：10.3969/j.issn.1009?6469.2020.07.043 |
| 中文关键词: 肺疾病，慢性阻塞性 /中药疗法 痰郁 益气祛瘀 半胱氨酸 组织型纤溶酶原激活物 纤溶酶原激活物抑制物 1 |
| 英文关键词: Pulmonary disease,chronic obstructive/zhong yao liao fa Phlegm depression Reinforcing qi removing stasis Cysteine Tissue plasminogen activator Plasminogen activator inhibitor |
| 基金项目:国家中医药管理局“十二五”中医药重点学科建设项目(国中医药办人教发〔2012〕32号)；国家中医药管理局第二届国医大师传承工作室建设项目(国中医药办人教发〔2015〕24号) |
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| 中文摘要: |
| 目的观察益气化痰祛瘀方对慢性阻塞性肺病( COPD)急性加重期病人血清同型半胱氨酸( Hcy)、组织纤溶酶原激活物(t?PA)、纤溶酶原激活物抑制物 ?1(PAI?1)水平的影响。方法将安徽中医药大学第一附属医院呼吸内科 2017年 6月至 2019年 9月收治住院的 60例 COPD急性加重期痰瘀阻肺型病人，按照受试者入选的先后顺序查阅随机对照表分为治疗组、对照组各 30例，对照组给予抗感染、化痰、解痉平喘等常规西医治疗，治疗组在此基础上服用中药益气化痰祛瘀方，治疗 14 d后观察两组症候积分比较、治疗前后 Hcy、t?PA、PAI?1水平。结果治疗后两组舌质积分改善不明显( P＞0.05)，其他症候积分较治疗前明显改善( P＜0.01)其中咳嗽、咳痰较对照组比较无明显差异( P＞0.05)喘息、纳呆、腹胀、口粘苔腻、面色或唇甲青紫方面优于对照组( P＜0.05或，P＜0.01)。两组治疗后 Hcy、PAI?1水平较治疗前明，显下降［( 15.59±2.79)比( 13.34±2.18)μmol/L、(61.13±8.30)比( 45.03±8.68)pg/mL，P＜0.05或 P＜0.01］t?PA水平较治疗前明显升高( 0.69±0.12)ng/mL，P＜0.01，且对照组优于治疗组( P＜0.05或 P＜0.01)。结论益气化痰祛瘀方可，能通过降低血 Hcy水平减轻内皮细胞损伤，改善纤溶失衡状态，从而有效缓解 COPD痰瘀阻肺证病人临床症候，延缓疾病进展。 |
| 英文摘要: |
| Objective To observe the effect of Yiqi Huatan Quyu Recipe on the levels of Hcy，t?PA and PAI?1 in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods From June 2017 to September 2019，60 AECO? PD patients from the respiratory department of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicinewere randomly divided into the treatment group and the control group with 30 cases in each group，according to the sequence ofsubjects selected and the random control table.The control group was treated with routine western medicine such as anti?infection， phlegm?resolving，spasmolysis and asthma?relieving.On this basis，the treatment group took Yiqi Huatan Quyu Recipe.After 14 days of treatment，the scores of symptoms，the levels of Hcy，t?PA and PAI?1 before and after treatment were observed.Results After treatment，there was no significant improvement in tongue integral between the two groups(P＞0.05).The scores of other symptoms were significantly improved compared with those before treatment(P＜0.01).There was no significant difference in cough and spu? tum between the two groups(P＞0.05).The symptoms of asthma，dullness，abdominal distension，greasy mouth，bluish complexion or purple lip nails of the control group were better than those of the control group(P＜0.05 or P＜0.01).After treatment，the levels of Hcy and PAI?1 in the two groups decreased significantly(15.59±2.79)vs.(13.34±2.18)μmol/L，(61.13±8.30)vs.(45.03±8.68) pg/mL，P＜0.05 or P＜0.01)and t?PA increased significantly(0.69±0.12 ng/mL，P＜0.01)，and the control group was better than the treatment group(P＜0.05 or P＜0.01).Conclusion Yiqi Huatan Quyu Prescription may reduce endothelial cell injury and im? prove fibrinolysis imbalance by reducing blood Hcy level，so as to effectively alleviate clinical symptoms of chronic obstructive pul?monary disease with phlegm and blood stasis obstruction and improve clinical efficacy. |
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