| 张建集,白格兰,边缓缓,等.口服复方甘草酸苷片联合静脉注射川芎嗪对酒精性肝病病人 T淋巴细胞的影响[J].安徽医药,2020,24(7):1453-1456. |
| 口服复方甘草酸苷片联合静脉注射川芎嗪对酒精性肝病病人 T淋巴细胞的影响 |
| Effects of oral compound glycyrrhizin tablets combined with intravenous injection of tetramethylpyrazine on T lymphocytes in patients with alcoholic liver disease |
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| DOI：10.3969/j.issn.1009?6469.2020.07.046 |
| 中文关键词: 肝疾病，酒精性 T淋巴细胞亚群 川芎嗪 层黏连蛋白 胶原 Ⅳ型 肿瘤坏死因子 α 瘦素 蛋白质 ?D?天门冬氨酸?L?异天门冬氨酸甲基转移酶 复方甘草酸苷片 |
| 英文关键词: Liver diseases,alcoholic T?Lymphocyte subsets Tetramethylpyrazine Laminin Collagen type IV Tumor necrosis factor?alpha Leptin Protein D?aspartate?L?isoaspartate methyltransferase Compound glycyrrhizin tablets |
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| 中文摘要: |
| 目的探讨复方甘草酸苷片联合川芎嗪对酒精性肝病病人 T淋巴细胞亚群的影响和临床疗效。方法选择 2016年 9月至 2018年 9月在石家庄市第五医院治疗的酒精性肝病病人 116例，按照随机数字表法分为两组，各 58例。对照组病人均采用川芎嗪治疗( 120 mg川芎嗪加入至 250 mL葡萄糖注射液中，静脉滴注， 1次/日)，观察组病人均在对照组基础上采用复方甘草酸苷片治疗(饭后口服，每次 50 mg，3次/日)。两组均接受 28 d的连续治疗，用药剂量依据病人年龄、症状等酌情加减。比较++两组 T淋巴细胞亚群［成熟 T淋巴细胞( CD3)、诱导性 T细胞 /辅助性 T细胞( CD4)、抑制性 T细胞 /细胞毒性 T细胞( CD8)］、肝纤维化指标［层粘连蛋白( LN)、透明质酸( HA)、 Ⅳ型胶原( CL?Ⅳ)］、细胞因子水平［肿瘤坏死因子 ?α(TNF?α)、转化生长因子 ?β(TGF?β1)、白细胞介素 ?6(IL?6)、瘦素( LP)］与肝功能指标［天门冬氨酸氨基转移酶( AST)、 γ?谷氨酰基转移酶( GGT)、丙氨酸氨基转移酶( ALT)］。结果治疗 28 d后，观察组 CD3(63.71±9.92)%与 CD4(38.99±8.26)%高于对照组(59.37±9.68)%、(35.75±6.12)%，CD8(28.63±5.62)%水平低于对照组( 31.35±6.17)%，LN(52.44±13.65)μg/L、HA(39.75±10.69)μg/L、CL?Ⅳ(69.88±14.55)μg/L、TNF?α(235.95±67.28)pg/L、TGF?β1(94.35±20.76)mg/L、IL?6(54.99±12.08)pg/L、LP(4.38±1.59)μg/L、AST(40.96± 12.08)U/L、GGT(36.28±14.53)U/L与 ALT(39.24±10.97)U/L水平均低于对照组 LN(52.44±13.65)μg/L、HA(39.75±10.69)μg/L、 CL?Ⅳ(69.88±14.55)μg/L、TNF?α(235.95±67.28)pg/L、TGF?β1(94.35±20.76)mg/L、IL?6(54.99±12.08)pg/L、LP(4.38±1.59)μg/L、 AST(40.96±12.08)U/L、GGT(36.28±14.53)U/L与 ALT(39.24±10.97)U/L水平，差异有统计学意义( P＜0.05)。结论酒精性肝病病人在川芎嗪治疗基础上，采用复方甘草酸苷片治疗，可有效改善 T淋巴细胞亚群水平，利于控制肝纤维化，调节细胞因子水平，改善肝功能。 |
| 英文摘要: |
| Objective To explore the effect of Compound Glycyrrhizin Tablets and Tetramethylpyrazine on T lymphocyte subsets inpatients with alcoholic liver disease.Methods A total of 116 patients with alcoholic liver disease treated in the Fifth Hospital Shi?jiazhuang from September 2016 to September 2018 were enrolled in the study.According to the random number table，they were di? vided into two groups，with 58 cases in each group.The patients in the control group were treated with Ligustrazine(120 mg Ligust? razine added to 250 ml glucose injection，intravenous drip，once a day)whereas those in the observation group were treated with Compound Glycyrrhizin Tablets plus treatment given to the control group(t，ake orally after meals，50mg each time，3 times/day). Both groups received continuous treatment for 28 days，and the dosage was increased or decreased according to the patient’s age and symptoms.The T lymphocyte subsets(CD3，CD4+ and CD8)and liver fibrosis indexes［Laminin(LN)，hyaluronic acid(HA) and type IV collagen(CL?IV)］cytokine levels［tumor necrosis factor?α(TNF?α)，transforming growth factor?β(TGF?β1)，inter? leukin?6(IL?6)andleptin(LP)］，and liver function indicators［aspartate aminotransferase(AST)，γ?glutamyl transferase(GGT)and alanine aminotransferase(ALT)］ were compared between the two groups. Results After 28 days of treatment，the CD3(63.71±9.92)%and CD4(38.99±8.26)%of the observation group were higher than those of the control group(59.37±9.68)%，(35.75±6.12)%,respectively，and the CD8(28.63±5.62)%level was lower than that in the control group(31.35±6.17)%，LN (52.44±13.65)μg/L，HA(39.75±10.69)μg/L，CL?Ⅳ(69.88±14.55)μg/L，TNF?α(235.95±67.28)pg/L，TGF?β1(94.35±20.76) mg/L，IL?6(54.99±12.08)pg/L，LP(4.38±1.59)μg/L，AST(40.96±12.08)U/L，GGT(36.28±14.53)U/L and ALT(39.24±10.97)U/L levels of the observation group were lower than those of the control group LN(52.44±13.65)μg/L，HA(39.75±10.69) μg/L，CL?Ⅳ(69.88±14.55)Μg/L，TNF?α(235.95±67.28)pg/L，TGF?β1(94.35±20.76)mg/L，IL?6(54.99±12.08)pg/L，LP(4.38±1.59)μg/L，AST(40.96±12.08)U/L，GGT(36.28±14.53)U/L and ALT(39.24±10.97)U/L，the differences werestatistical? ly significant(P＜0.05).Conclusion For patients with alcoholic liver disease，Compound Glycyrrhizin Tablets combined with Li?gustrazine can help improve the levels of T lymphocyte subsets and control the level of liver fibrosis，regulate cytokine levels and improve their liver function. |
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