| 黄学勤,赵萍,武玲,等.巴曲酶联合银杏叶提取物注射液治疗突发性聋的临床随机对照试验 Meta分析[J].安徽医药,2020,24(8):1494-1497. |
| 巴曲酶联合银杏叶提取物注射液治疗突发性聋的临床随机对照试验 Meta分析 |
| Meta?analysis of clinical randomized control study of batroxobin combined with ginkgo biloba extract injection treating sudden deafness |
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| DOI：10.3969/j.issn.1009?6469.2020.08.002 |
| 中文关键词: 听觉丧失，突发性/药物疗法 巴曲酶 银杏叶提取物 Meta分析 |
| 英文关键词: Hearing loss,sudden/drug therapy Batroxobin Ginkgo biloba extract Meta?analysis |
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| 中文摘要: |
| 目的评价巴曲酶联合银杏叶提取物注射液治疗突发性聋的临床疗效，为临床的推广应用提供依据。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库收录的有关巴曲酶和银杏叶提取物注射液联合治疗突发性聋的临床效果分析的文章，检索年限从建库至 2019年 4月。根据纳入和排除标准纳入文献及提取资料，采用 Rev Man 5.3软件进行 Meta分析。纳入 Meta分析的文献共 13篇，均为临床随机对照治疗研究，包含 1 274个研究对象，比较联合用药的观察组与单一用药的对照组突发性聋的总有效率。结果两组治疗突发性聋的疗效比较，差异有统计学意义(RR＝1.21，95%CI:1.15~1.27，Z＝7.64，P＜ 0.01)。结论使用巴曲酶联合银杏叶提取物注射液治疗突发性聋疗效显著，值得在临床中推广应用。 |
| 英文摘要: |
| Objective To evaluate the clinical efficacy of batroxobin combined with ginkgo biloba extract injection in the treatment of sudden deafness，and provide a basis for clinical application.Methods Computers were searched for articles on the clinical ef?fects of Batroxobin and Ginkgo biloba extract injections in the treatment of sudden deafness，which were included in the China Knowledge Network，Wanfang，Weipu，and China Biomedical Literature Database.The search period is from the establishment of thelibrary to April 2019.Meta?analysis was performed using Rev Man 5.3 software based on inclusion and exclusion criteria for inclu?sion in the literature and extraction of data.A total of 13 articles included in the Meta?analysis were randomized controlled trials，in? cluding 1274 subjects.The total effective rate of sudden deafness was compared between the observation group and the single?drugcontrol group.Results There was a statistically significant difference between the two groups in the treatment of curative effect of sudden deafness(RR＝1.21，95%CI:1.15?1.27，Z＝7.64，P＜0.01).Conclusion The use of batroxobin combined with ginkgo bi?loba extract injection for the treatment of sudden deafness has significant efficacy and is worthy of popularization and application inclinical practice. |
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