| 金良,徐江,汪丹青,等.华法林预测剂量在下肢深静脉血栓病人初始抗凝治疗中的应用价值[J].安徽医药,2020,24(8):1632-1635. |
| 华法林预测剂量在下肢深静脉血栓病人初始抗凝治疗中的应用价值 |
| The application value of the initial anticoagulant treatment in the lower extremity deep vein thrombosis patients with predicted dose of warfarin |
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| DOI：10.3969/j.issn.1009?6469.2020.08.040 |
| 中文关键词: 静脉血栓形成 下肢 抗凝 国际标准化比 华法林稳态剂量 遗传基因多态性 |
| 英文关键词: Venous thrombosis Lower extremity Anticoagulation International normalized ratio Steady state dose of warfarin Genetic polymorphism |
| 基金项目:铜陵市卫生与计划生育委员会面上项目(卫科研［2016］22号) |
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| 中文摘要: |
| 目的探讨下肢深静脉血栓病人采用华法林预测剂量作为初始抗凝剂量的价值。方法回顾性收集 2014年 10月至 2018年 2月铜陵市人民医院采用华法林进行长期抗凝治疗的下肢深静脉血栓病人 57例资料，其中观察组 14例，采用预测剂量作为起始剂量；对照组 43例，采用固定起始剂量。比较两组性别组成、年龄结构、体质量，华法林起始剂量、稳态剂量、首次达标时间、出血性并发症等。结果两组病人在性别、年龄、体质量、华法林稳态剂量、出血并发症方面差异无统计学意义(P＞ 0.05)观察组与对照组华法林起始剂量［(3.2±0.7)mg/d比(2.5±0.6)mg/d］、首次达标时间［(5.0±1.7)d比(10.0±4.1)d］差异有统计学(P＜0.05)。结论预测华法林稳态剂量不一定改善传统抗凝方法的效果，但可以缩短首次达标时间，减少药物剂量意义，调整频率和幅度，并且提高治疗达标的时间百分比。 |
| 英文摘要: |
| Objective To discuss the value of the predicted dose of warfarin as initial anticoagulant dose in the patients with lowerextremity deep vein thrombosis.Methods Data of 57 patients with deep vein thrombosis of lower extremities treated with warfarinfor long?term anticoagulant therapy in Tongling People’s Hospital from October 2014 to February 2018 were collected retrospective? ly，including 14 patients in the observation group with the predicted initial dose and 43 patients in the control group with the fixedinitial dose.The differences in gender composition，age structure，body weight，initial dose and steady state dose of warfarin，the initial time of meet the standards，and hemorrhagic complications were compared between the two groups.Results There was no statistical difference between the two groups in terms of gender，age，weight，steady state dose of warfarin，and complications of hemorrhage(P＞0.05)，and there was a statistical difference between the initial dose［(3.2±0.7)mg/d vs.(2.5±0.6)mg/d］and the initial time of meet the standards［(5.0±1.7)d vs.(10.0±4.1)d］(P＜0.05).Conclusion The prediction of the steady state dose of the warfarin is not necessarily improving the effect of the traditional anticoagulant method，but it will shorten the initial time of meet the standards，re? ducing the frequency and amplitude of drug doses adjustment，and it may improve the percentage of time that is met. |
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