| 王鹏,荀艳,赵艺,等.头孢菌素类药物说明书 976份中皮肤过敏试验、交叉过敏警示标志分析[J].安徽医药,2020,24(8):1659-1663. |
| 头孢菌素类药物说明书 976份中皮肤过敏试验、交叉过敏警示标志分析 |
| Analysis of warning signs of skin allergy test and cross?allergy in 976 cephalosporin antibacterial instructions |
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| DOI：10.3969/j.issn.1009?6469.2020.08.047 |
| 中文关键词: 药物标签 说明书 头孢菌素类 药物过敏 药物警戒性 皮试 交叉过敏 |
| 英文关键词: Drug labeling Prospectuses Cephalosporins Drug hypersensitivity Pharmacovigilance Skin test Cross?allergy |
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| 摘要点击次数: 1839 |
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| 中文摘要: |
| 目的通过搜集临床常用头孢菌素类药物说明书，了解其中关于皮肤过敏试验及其警示语相关规定，强调临床规范头孢菌素皮试的重要性。方法搜集芜湖市第二人民医院 2018年 3月至 2019年 3月 15种头孢菌素类药物说明书共 976份，对说明书中的厂家、规格、皮试要求、警示语、禁忌等内容通过 Excel分类汇总及分析。结果 15种头孢菌素药物中有 5个品种，共计 144份说明书强调在使用前建议进行皮肤过敏试验； 140份说明书有交叉过敏警示标志，但描述各不相同。部分药品如头孢克肟、头孢曲松、头孢哌酮舒巴坦、头孢米诺尽管同一通用名，但不同厂家的警示标志也不相同。结论目前头孢菌素类药物说明书中关于皮试内容不规范，且对于交叉过敏过度夸大，一定程度上造成临床滥用皮试，应加以规范。 |
| 英文摘要: |
| Objective To understand the importance of the clinical standard cephalosporin skin test by collecting the clinical com?mon cephalosporin drug specifications and understanding the relevant regulations on skin sensitivity test and warning signs.Meth? ods A total of 976 instructions of 15 cephalosporin drugs were collected in The Second People’s Hospital of Wuhu，Wuhu form March 2018 to March 2019.The manufacturers，specifications，skin to test requirements，warnings，taboos，etc.in the manual were classified and analyzed by Excel.Results There were 5 varieties of the 15 cephalosporin drugs，a total of 144 instructions empha? sized the recommended skin sensitivity test before use；140 instructions had cross?allergy warning signs，but the descriptions were different.Some drugs such as cefaclor，ceftriaxone，cefoperazone sulbactam and cefminox had the same common name，but the warn? ing signs of different manufacturers were also different.Conclusion At present，the content of the skin test of the cephalosporindrug specification is not standardized and the exaggeration of cross?allergy is excessive，which causes clinical abuse of skin to test to a certain extent and should be regulated. |
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