文章摘要
张冬燕,齐艳霞,马培志.基于 logistic回归模型的前列地尔注射液引起静脉炎危险因素分析[J].安徽医药,2020,24(8):1663-1665.
基于 logistic回归模型的前列地尔注射液引起静脉炎危险因素分析
Analysis of risk factors of alprostadil injection induced phlebitis based on logistics regression model
  
DOI:10.3969/j.issn.1009?6469.2020.08.048
中文关键词: 前列地尔/副作用  静脉炎  危险因素  logistic回归
英文关键词: Alprostadil/adverse effects  Phlebitis  Risk factor  logistic regression
基金项目:
作者单位E-mail
张冬燕 河南省人民医院药学部河南郑州 450003  
齐艳霞 河南省人民医院药学部河南郑州 450003  
马培志 河南省人民医院药学部河南郑州 450003 mpeizhi@163.com 
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中文摘要:
      目的研究前列地尔注射液发生静脉炎相关的危险因素,为临床应用中减少静脉炎的发生提供参考。方法收集 2018年 1—12月河南省人民医院输注前列地尔注射液发生静脉炎的所有病历共 29份作为试验组,收集 364例同期输注前列地尔的无静脉炎的住院病人作为对照组,对致静脉炎的可能危险因素进行单因素分析及多因素非条件 logistic回归分析。结果单因素分析及多因素非条件二元 logistic回归分析结果均显示,病人过敏史、用药剂量、溶媒体积 3个因素在试验组与对照组之间的差异有统计学意义(P<0.05),是前列地尔注射液引起静脉炎的独立危险因素。结论临床使用前列地尔注射液时,应加强过敏史、用药剂量、溶媒体积等危险因素的用药管理,规范使用,减少不必要的静脉炎发生。
英文摘要:
      Objective To investigate related risk factors of alprostadil injection induced phlebitis,and provide a reference for the prevention of the reaction.Methods Totally 29 clinical medical records of alprostadil injection induced phlebitis in Henan Provin? cial People’s Hospital from January to December 2018 were collected as experimental group;364 medical records without alprosta?dil injection induced phlebitis during the same period were included as control group.The single factor analysis and multivariate lo?gistic regression analysis were conducted for the potential risk factors.Results Results of single factor analysis and multivariate lo?gistic regression analysis showed that there was statistical significance in 3 factors including the history of allergy,dosage and sol? vent volume between experimental group and control group(P<0.05),and they were independent risk factors to alprostadil injec? tion induced phlebitis.Conclusion During the clinical application of alprostadil injection,great importance should be attached for the risk factors,including history of allergy,dosage and solvent volume,so as to prevent unnecessary allergic reactions effectively.
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