| 李海燕,王惠川,闵慧,等.某医院 2016—2019年造影剂相关不良反应 77例分析[J].安徽医药,2020,24(8):1689-1692. |
| 某医院 2016—2019年造影剂相关不良反应 77例分析 |
| Retrospective analysis of 77 cases of adverse drug reactions induced by contrast agent in a hospital from 2016 to 2019 |
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| DOI：10.3969/j.issn.1009?6469.2020.08.055 |
| 中文关键词: 造影剂/副作用 过敏反应 不良反应 用药安全 |
| 英文关键词: Contrast agen/adverse effects Anaphylaxis Adverse drug reaction Safe medication |
| 基金项目:陕西省重点研发计划项目(2018SF?319)；西安市第四医院科研孵化基金—2018年度学科发展科技支持项目(FZ?19) |
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| 中文摘要: |
| 目的分析造影剂在临床应用中不良反应的发生特点，为临床合理使用造影剂提供参考。方法回顾性分析西安市第四医院 2016年 1月至 2019年 12月上报的造影剂相关不良反应(ADR)报告表，分析 ADR病人的年龄、性别、严重程度、疾病分布、 ADR的发生时间，累及系统 /器官及主要临床表现， ADR的处理及结果等。结果造影剂相关不良反应报告共 77例，其中 3例为严重不良反应。共涉及造影剂 5个品种，居前 3位的分别为碘海醇、碘佛醇及钆喷酸葡胺。＞ 50~70岁年龄组 ADR发生比例较高，占比为 58.44%。药品不良反应主要发生在试敏(6例， 85.71%)和给药后 10 min以内(31例， 49.21%)临床表现以皮肤及附件损害所占比例最大(43例， 34.13%)、其次为消化系统损害(23例， 18.25%)，第三为循环系统损害(21例，1，6.67%)。结论造影剂在临床使用时应加强对其用药风险评估及相关 ADR的主动监测，确保临床用药安全。 |
| 英文摘要: |
| Objective To analyze problems of contrast agents used in clinic and the characteristics of contrast agent adverse drug reactions(ADRs)，and provide a reference for rational use of contras agents.Methods The adverse drug reaction(ADR)reportsof contrast agents in the Fourth Hospital of Xi’an from January 2016 to December 2018 were retrospectively analyzed.The gender， age，severity，distribution of disease，occurrence time，affecting system and organs，main clinical manifestations，and ADR processing and results of ADR?related patients were analyzed.Results A total of 77 cases of contrast agent?induced ADRs，which were 3 cas? es of severe ADRs.The 77 cases of ADR involved 5 varieties of contrast agent，the top three were iohexol，ioversol and gadopen? tetate dimeglumine.The proportion of contrast agent?induced ADR was significantly higher in the group of＞50?70 years of age， which was 58.44%.The ADR mainly occurred in skin test(6 cases，85.71%)and 10 minutes after medication(31 cases，49.21%)and the clinical manifestations was skin and local lesion(43 cases，34.13%)， followed by gastro?intestinal damage(23 cases，18.25%)and circulation system damage(21 cases，16.67%).Conclusion In the clinical use of contrast agents，it is necessary tostrengthen the risk assessment of contrast agents and the monitoring of related ADR to ensure the safety of clinical medication. |
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