| 郭伟,陈小爽,王晓磊,等.共刺激因子 B7同源体 4蛋白在胆囊腺瘤和胆囊腺癌中的表达[J].安徽医药,2021,25(1):44-47. |
| 共刺激因子 B7同源体 4蛋白在胆囊腺瘤和胆囊腺癌中的表达 |
| The expression of B7?H4 protein in gallbladder adenocarcinoma and gallbladder adenoma |
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| DOI：10.3969/j.issn.1009?6469.2021.01.011. |
| 中文关键词: 胆囊肿瘤 共刺激因子 B7同源体 4 细胞分化 肿瘤分期 癌变 生存， |
| 英文关键词: Gallbladder neoplasms Costimulatory factor B7 homolog 4 Cell differentiation Neoplasm staging Carcinogenesis |
| 基金项目:河南省医学科技攻关联合共建项目(LHGJ20190512)；河南省高等学校重点科研项目(18A320020)；开封市科技发展计划(130351) |
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| 中文摘要: |
| 目的研究 B7?H4(B7同源物 4)蛋白在胆囊腺瘤恶变为胆囊腺癌过程中的意义。方法选取河南大学第一附属医院 2005年 6月至 2015年 6月符合条件胆囊腺癌病例共 58例，采用免疫组织化学法检测 B7?H4在胆囊腺瘤和胆囊腺癌中的表达。应用 SPSS 17.O软件包对其表达分析，所有结果 α＝0.05(双侧)检验水准。结果 B7?H4蛋白在胆囊腺瘤阳性表达率为 15.00%(6/40)，在胆囊腺癌阳性表达率为 67.24%(39/58)，差异有统计学意义(χ2＝26.017，P＜0.05)。 B7?H4蛋白在胆囊腺癌低?中分化组阳性表达率为 69.44%(25/36)，在高分化组的阳性表达率为 33.33%(4/12)，差异有统计学意义(χ2＝4.907，P＝0.027)。B7?H4在胆囊腺癌 TNM(Ⅰ+Ⅱ)和 TNM(Ⅲ+Ⅳ)中表达差异无统计学意义(χ2＝2.379，P＝0.123)。B7?H4阳性表达与病人的年龄和性别无相关(χ2＝0.005，P＝0.944)与伴胆囊结石(χ2＝7.608，P＝0.006)、肿瘤长径(χ2＝6.522，P＝0.011)、淋巴结转移(χ2＝3.928，P＝0.047)相关。 Kaplan?Meier分析: B7?H4阳性表达组中位生存率为 26月， 95%CI:20.661～31.339，B7?H4蛋白阴性表达组中位生存期为 22月， 95%CI:6.359～37.641，Log?Rank(Mantel?Cox)显示: B7?H4蛋白表达阳性者与表达阴性者三年生存期差异无统计学意义(χ2＝0.187，P＝0.665)。结论 B7?H4蛋白在胆囊腺癌中表达明显高于胆囊腺瘤。 B7?H4蛋白的阳性表达与胆囊腺癌的分化程度、肿瘤长径、胆囊结石及淋巴结转移相关，与胆囊病理分期、年龄、性别无相关。 |
| 英文摘要: |
| Objective To explore the significance of B7?H4 in the process of gallbladder adenoma becoming gallbladder adeno? carcinoma.Methods A total of 58 eligible cases of gallbladder adenocarcinoma from June 2005 to June 2015 in the First AffiliatedHospital of Henan University were selected，and the expression of B7?H4 in gallbladder adenocarcinoma and gallbladder adenomawas detected by immunohistochemistry.SPSS17.0 software package was used to analyze its expression，all results α＝0.05(bilater? al)test level，P＜0.05 was statistically significant.Results The positive expression rate of B7?H4 protein in gallbladder adenoma was 15.00%(6/40)，and the positive expression rate in gallbladder adenocarcinoma was 67.24%(39/58)，the difference was statis? tically significant(χ2＝26.017，P＜0.05).The positive expression rate of B7?H4 protein in the low?medium differentiated group of gallbladder adenocarcinoma was 69.44%(25/36)，and the positive expression rate in the well?differentiated group was 33.33%(4/ 12)，the difference was statistically significant(χ2＝4.907，P＝0.027).There was no significant difference in the expression of B7? H4 in gallbladder adenocarcinoma TNM(Ⅰ+Ⅱ)and TNM(Ⅲ+Ⅳ)(χ2＝2.379，P＝0.123).The positive expression of B7?H4 was not correlated with the age and gender(χ2＝0.005，P＝0.944)，but was correlated with gallbladder stones(χ2＝7.608，P＝0.006)， tumor diameter(χ2＝6.522，P＝0.011)，lymph nodes Metastasis(χ2＝3.928，P＝0.047).Kaplan?Meier survival analysis:The medi? an survival rate of the B7?H4 positive expression group was 26 months，95%CI:20.661?31.339，the median survival time of the B7? H4 protein negative expression group was 22 months，95%CI:6.359?37.641，Log?Rank(Mantel?Cox)showed that there was no sig?nificant difference in the three?year survival between B7?H4 protein expression positive and negative expression(χ2＝0.187，P＝0.665).Conclusions The expression of B7?H4 protein in gallbladder adenocarcinoma is significantly higher than that in gallblad?der adenoma.The positive expression of B7?H4 protein is associated with the degree of differentiation，tumor diameter，gallstone of gallbladder adenocarcinoma and lymph node metastasis，and is not associated with pathological stage，age and gender of gallbladder. |
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