| 何立香,周宇,王美清,等.术前和术后中性粒细胞与淋巴细胞比值变化预测结直肠癌病人预后的研究[J].安徽医药,2021,25(1):84-88. |
| 术前和术后中性粒细胞与淋巴细胞比值变化预测结直肠癌病人预后的研究 |
| Preoperative and postoperative changes of neutrophil?to?lymphocyte ratio in predicting prognosis of patients with colorectal cancer |
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| DOI：10.3969/j.issn.1009?6469.2021.01.021. |
| 中文关键词: 中性粒细胞与淋巴细胞比值 结直肠肿瘤 总生存率 无病生存率 预后 |
| 英文关键词: Neutrophil?to?lymphocyte ratio Colorectal neoplasms Overall survival rate Disease?free survival rate Prognosis |
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| 摘要点击次数: 1609 |
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| 中文摘要: |
| 目的探讨术前和术后中性粒细胞与淋巴细胞比值(Neutrophil?to?lymphocyte ratio，NLR)变化(ΔNLR)对结直肠癌病人预后的预测价值。方法收集 2010年 1月至 2013年 12月中南大学湘雅医学院附属海口医院行手术切除治疗的结直肠癌病人 120例作为研究对象。根据受试者工作特征曲线(ROC)选定 ΔNLR最佳分界值，将病人分为 ΔNLR≤0.038组(n＝36)和 ΔNLR＞0.038组(n＝84)。 ΔNLR与结直肠癌病人临床病理特征的关系采用 χ2检验，影响结直肠癌病人总生存率(OS)和无病生存率(DFS)的单因素、多因素采用 Cox比例风险模型分析，生存曲线绘制采用 Kaplan?Meier法，比较采用 Log?Rank法。结果 ΔNLR≤0.038组病人中性别、年龄、吸烟史、嗜酒史、卡氏评分、原发肿瘤位置与 ΔNLR＞0.038组比较，差异无统计学意义(均 P＞0.05)； ΔNLR≤0.038组病人中腹腔镜手术 41.67%、辅助治疗 36.11%、癌胚抗原＞ 5 μg/L 30.56%、TNM分期 Ⅲ~Ⅳ期 16.67%、中高分化 22.22%低于 ΔNLR＞0.038组腹腔镜手术 71.43%、辅助治疗 59.52%、癌胚抗原＞ 5 μg/L占 64.29%、TNM分期 Ⅲ~Ⅳ期 57.14%、中高分化 58.33%，差异有统计学意义(均 P＜0.05)。单因素预后分析结果显示，癌胚抗原、 TNM分期、分化程度、 ΔNLR是影响结直肠癌病人 OS、DFS的危险因素(均 P＜0.05)；多因素预后分析结果显示， ΔNLR是影响结直肠癌病人 OS的危险因素(P＜0.05)癌胚抗原、 ΔNLR是影响结直肠癌病人 DFS的危险因素(均 P＜0.05)。 ΔNLR≤0.038组病人 5年 OS、DFS分别为 88.89%和 81.26高于 ΔNLR＞0.038组病人的 58.33%、55.25%，差异有统计学意义(均 P＜0.05)。结论 ΔNLR可作为%，预测结直肠癌病人预后的重要指标， ΔNLR高者预后差。 |
| 英文摘要: |
| Objective To investigate the predictive value of ΔNLR before and after operationin the prognosis of patients with colorectal cancer.Methods A total of 120 patients with colorectal cancer who underwent surgical resection in Haikou AffiliatedHospital of Xiangya Medical College of Central South University from Jan 2010 to Dec 2013 were selected as study subjects.Thepatients were divided into ΔNLR≤0.038 group(n＝36)and ΔNLR＞0.038 group(n＝84)according to the optimal threshold of ΔNLR determined by ROC.χ2test was used to examine the relationship between ΔNLR and clinicopathological characteristics of pa?tients with colorectal cancer.Cox proportional risk model was used to analyze univariate and multivariate factors affecting OS andDFS in patients with colorectal cancer.Kaplan?Meier method was used to draw survival curve and Log?Rank method was used tocompare.Results There was no significant difference in sex，age，smoking history，alcohol addiction，Karl’s score，location of prima? ry tumors between ΔNLR≤0.038 group and ΔNLR＞0.038 group(both P＞0.05)； In the ΔNLR≤0.038 group，41.67% of laparoscop? ic surgery，36.11% of adjuvant therapy，30.56% of carcinoembryonic antigen＞5 μg/L，16.67% of TNM stage Ⅲ~Ⅳ stage and |
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