| 黄珍,归奕飞,廖文勇,等.前哨淋巴结阳性乳腺癌病人发生非前哨淋巴结转移的危险因素分析[J].安徽医药,2021,25(1):100-103. |
| 前哨淋巴结阳性乳腺癌病人发生非前哨淋巴结转移的危险因素分析 |
| Risk factors for non?sentinel lymph node metastasis in patients with positive sentinel lymph node |
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| DOI：10.3969/j.issn.1009?6469.2021.01.025. |
| 中文关键词: 乳腺肿瘤 前哨淋巴结活组织检查 肿瘤微转移 脉管侵犯 组织学分级 非前哨淋巴结 危险因素 |
| 英文关键词: Breast neoplasms Sentinel lymph node biopsy Neoplasm micrometastasis Histological grade Lymphovas? cular invasion Non?sentinel lymph node Risk factor |
| 基金项目:广西壮族自治区卫生健康委员会自筹课题(Z20200134) |
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| 中文摘要: |
| 目的探讨前哨淋巴结(SLN)阳性病人发生非前哨淋巴结(NSLN)转移的相关危险因素。方法回顾性分析 2014年 1月至 2019年 2月于柳州市工人医院行前哨淋巴结活检(SLNB)的 552例乳腺癌病人的临床病理资料，采用单变量与多变量分析 SLN阳性病人发生 NSLN转移的相关危险因素。结果 552例行 SLNB的乳腺癌病人中 SLN阳性病人占 18.3%(101例)，进一步行腋窝淋巴结清扫(ALND)术后病理资料显示共 37.6%(38例)病人发生 NSLN转移。单因素分析提示， SLN阳性数目(t＝21.127，P＜0.001)、癌灶长径(21.30±2.18)比(30.60±1.17)mm、组织学分级(t＝8.868，P＝0.012)、脉管侵犯情况(t＝23.732，P＜ |
| 英文摘要: |
| Objective To investigate the risk factors for non?sentinel lymph node(NSLN)metastasis in patients with positive sen? tinel lymph node(SLN).Methods The clinicopathological factors of 552 patients with breast cancer who underwent sentinel lymph node biopsy(SLNB)in Liuzhou Worker’s Hospital from January 2014 to February 2019 were retrospectively analyzed.Univariateand multivariate analysis were used to analyze the related factors affecting the status of NSLN in patients with positive SLN.Results Among 552 patients who underwent SLNB，SLN?positive patients accounted for 18.3%(101 cases).The pathological data after further axillary lymph node dissection(ALND)showed that 37.6%(n＝38)patients had NSLN metastasis.Univariate analysis indicated that the number of positive sentinel lymph node(t＝21.127，P＜0.001)the invasive tumor size(21.30±2.18)vs.(30.60±1.17)mm，histological grade(t＝8.868，P＝0.012)lymphovascular invasion(LV(t＝23.732，P＜0.001)，and hormone receptor(ER/PR)status(t＝4.098， y correlated with NSLN metastasis.The number of positive SLN(P＜0.001，OR:3.230，95% CI:1.676?6.225)，the invasive tumor size(P＝0.008；OR:4.400；95% CI:1.469?13.182)，histological grade(P＝0.007，OR:1.980，95% CI:1.202?3.263)and LVI(P＝0.005，OR:3.380，95% CI:1.432?7.980)were significant influencing factorsfor NSLN metas? tasis as indicated bythe multivariate analysis.Conclusions In patients with positive SLN，the number of positiveSLN(≥3)，large mass，high histological grade and LVI are closely related to NSLN metastasis.ALND is still the standard treatment for these patients. |
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