| 曹邓晗,王志宏.阿卡波糖治疗 2型糖尿病及对血清炎性因子、抑胃肽、胰升血糖素样肽 ?1、空腹 C肽的影响[J].安徽医药,2021,25(1):140-143. |
| 阿卡波糖治疗 2型糖尿病及对血清炎性因子、抑胃肽、胰升血糖素样肽 ?1、空腹 C肽的影响 |
| Effects of acarbose on type 2 diabetes mellitus and serum inflammatory factor，gastric inhibitory peptide，glucagon?like peptide?1 and fasting C?Peptide |
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| DOI：10.3969/j.issn.1009?6469.2021.01.035. |
| 中文关键词: 糖尿病， 2型 阿卡波糖 炎性因子 抑胃肽 胰升血糖素样肽 ?1 C肽 |
| 英文关键词: Diabetes mellitus,type 2 Acarbose Inflammatory factor Gastric inhibitory peptides Glucagon like peptide?1 C?peptide |
| 基金项目:河南省医学科技攻关计划联合共建项目(LHGJ20191005) |
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| 中文摘要: |
| 目的研究阿卡波糖治疗 2型糖尿病(T2DM)及对血清炎性因子、抑胃肽(GIP)、胰升血糖素样肽 ?1(GLP?1)、空腹 C肽(C?P)的影响。方法选择郑州市第一人民医院 2014年 7月至 2018年 6月收治的 T2DM病人 238例，按照随机数字表法分为阿卡波糖组与对照组，各 119例。对照组给予甘精胰岛素治疗，阿卡波糖组在对照组基础上给予阿卡波糖治疗。观察两组血清空腹血糖(FPG)、餐后 2h血糖(2 h PG)及糖化血红蛋白(HbA1c)等指标治疗前后的差异，观察 GIP、GLP?1、C?P、白介素 ?4(IL?4)、白介素 ?6(IL?6)、白介素 ?10(IL?10)等治疗前后水平的变化及两组间的不良反应。结果治疗后，阿卡波糖组 FPG |
| 英文摘要: |
| Objective To study the effects of acarbose on Type 2 diabetes mellitus(T2DM)and serum Inflammatory factors，gas? tric inhibitory peptide(GIP)，glucagon?like peptide?1(GLP?1)and fasting C?Peptide(C?P).Methods A total of 238 T2DM pa? tients admitted to Zhengzhou First People’s Hospital from July 2014 to June 2018 were selected and divided into acarbose groupand control group according to the random number table method，with 119 cases in each group.The control group was treated withinsulin glargine and the Acarbose group was treated with acarbose on the basis of the control group.The differences of serum fastingplasma glucose(FPG)，2h postprandial glucose(2hPG)and glycated hemoglobin(HbA1c)between the two groups before and af? ter treatment were observed.The differences of serum GIP，GLP?1，C?P，IL?4，IL?6 and IL?10 between the two groups before and af? ter treatment，and adverse reactions were observed.Results After treatment，the levels of FPG(5.07±0.52)mmol/L，2 h PG(7.58±0.77)mmol/L，HbA1c(6.07±0.62)%，GIP(1 203.58±123.83)μg/L，IL?6(2.08±0.22)ng/L in the acarbose group were lower than those in the control group FPG(6.22±0.63)mmol/L，2 h PG(9.71±0.99)mmol/L，HbA1c(7.18±0.73)%，GIP(1 394.38±142.55) μg/L，IL?6(2.67±0.28)ng/L，and the levels of IL?4(4.60±0.48)ng/L，IL?10(1.43±0.16)ng/L，GLP?1(26.85±2.67)pmol/L，C?P(2.48±0.26)μg/L were all higher than those in the control group IL?4(4.14±0.44)ng/L，IL?10(1.18±0.13)ng/L，GLP?1(23.64±2.46)pmol/L，C?P(2.21±0.24)μg/L(P＜0.05).There was no difference in the incidence of adverse reactions between the acarbose group(10.92%)and the control group(5.04%)(P＞0.05).Conclusion Acarbose can effectively reduce the blood glucose level in patients with T2DM，inhibit inflammatory response，promote recovery of GIP，GLP?1 and C?P，which is safe and reliable. |
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