| 张宁,张爱民,王冉,等.右美托咪定与利多卡因预处理对全麻诱导时依托咪酯不良反应的影响[J].安徽医药,2021,25(1):152-155. |
| 右美托咪定与利多卡因预处理对全麻诱导时依托咪酯不良反应的影响 |
| Effect of dexmedetomidine and lidocaine pretreatment on adverse reactions of etomidate during general anesthesia induction |
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| DOI：10.3969/j.issn.1009?6469.2021.01.038. |
| 中文关键词: 依托咪酯 药物相关性副作用和不良反应 麻醉，全身 右美托咪定 利多卡因 肌阵挛 注射痛 |
| 英文关键词: Etomidate Drug?related side effects and adverse reactions Anesthesia,general Dexmedetomidine Lidocaine Myoclonus Injection pain |
| 基金项目:邯郸市科学技术研究与发展计划(1623208065?3) |
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| 中文摘要: |
| 目的观察右美托咪定与利多卡因预处理对全身麻醉诱导期依托咪酯注射痛及肌阵挛的影响。方法选择 2018年 6月至 2019年 6月河北工程大学附属医院择期手术全麻病人 144例， ASA分级 Ⅰ～Ⅱ，采用随机数字表法分为三组:对照组(C组)、右美托咪定组(D组)、利多卡因组(L组)每组 48例。 D组和 L组病人分别预先泵注右美托咪定 0.5 μg/kg和利多卡因 1 mg/kg；C组给予等容量 0.9%氯化钠溶液(10 mL)，，均在 10 min注射完毕。然后各组病人静脉推注依托咪酯 0.3 mg/kg，注射时间 30 s。分别干预给药前(T0)、给依托咪酯前(T1)、及给依托咪酯后 1 min(T2)、 2 min(T3)记录病人 HR(心率)、 MAP(平均动脉压)、 SpO2镇静评分，低血压和心动过缓发生率，评估肌阵挛发生情况及严重程度。结果与 C(血氧饱和度)、并记录注射痛、组比较， D组和 L组的肌阵挛发生率明显降低(P＜0.05)；而 D组与 L组之间肌阵挛发生率及程度差异无统计学意义。 D组镇静评分明显高于 C组和 L组(P＜0.05)；与 C组比较， D组和 L组的注射痛发生率明显降低(P＜0.05)；而 D组与 L组之间注射痛发生率差异无统计学意义。各组均无低血压和心动过缓发生。 D组和 L组 MAP均在 T(179.5±6.4)、 T2T3 |
| 英文摘要: |
| Objective To observe the effect of dexmedetomidine and lidocaine pretreatment on injection pain and myoclonus ofetomidate during general anesthesia induction.Methods From June 2018 to June 2019，144 patients(ASAⅠ～Ⅱ)had surgery dur? ing this period were randomly divided into3 groups(N＝48)control group(Group C)Dex group(Group D)，and lidocaine grou(GroupL)byr and omnum bertablemethod.Patientsin Group Da:ndGroupLreceivedintra，venous Dex 0.5 μg/kg and lidocaine 1 mg/kg respectively，while patients in group C received intravenous normal saline with the same volume(10 mL)within10 min.Then etomidate 0.3 mg/kg was injected intravenously for 30 s.Heart rate(HR)，mean arterial pressure(MAP)，oxygen saturation(SpO2)and Ramsay score were recorded before drug(T0)to etomidate before(T1)and to 1 min(T2)，2 min(T3)after etomidate.The adverse ef? fectssuchasinjectionpainandadversecardiova，scular events were also recorded.The onset of myoclonus was observed and the sever?ity was recorded.Results Compared with group C，the incidence of myoclonus in group D and group L was significantly lower(P＜0.05)，but there was no significant difference in the incidence and degree of myoclonus between group D and group L.Sendationscore in Group D was significantly higher than the other two groups(P＜0.05).Comparing to group C，the incidence of pain in Group C was significantly higher than that in Group L and Group D(P＜0.05).The frequency of etomidate injection pain were statisticallysimilar between Group L and Group D.No hypotension and bradycardia occurred in all groups.The groups D and groups L of MAPwere gradually lower at T(179.5±6.4)T2，(66.9±5.4)mmHg time point；The groups C and groups L of HR were gradually |
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