| 陶扬洋,倪磊,王昊珏,等.克霉唑阴道片联合口服替勃龙治疗真菌性阴道炎疗效及对血清雌二醇、卵泡刺激素水平的影响[J].安徽医药,2021,25(1):160-163. |
| 克霉唑阴道片联合口服替勃龙治疗真菌性阴道炎疗效及对血清雌二醇、卵泡刺激素水平的影响 |
| Effect of clotrimazole vaginal tablets combined with oral tibolone on mycotic vaginitis and serum estradiol and follicle stimulating hormone levels |
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| DOI：10.3969/j.issn.1009?6469.2021.01.040. |
| 中文关键词: 阴道炎 真菌 克霉唑阴道片 雌二醇 卵泡刺激素 替勃龙 疗效 |
| 英文关键词: Vaginitis Fungi Clotrimazole vaginal tablets Estradiol Follicle?stimulating hormone Tibolone Efficacy |
| 基金项目:无锡市科技发展指导性计划(医疗卫生)项目(CSZON1620) |
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| 中文摘要: |
| 目的分析联合应用克霉唑阴道片与替勃龙治疗真菌性阴道炎的效果及对血清雌二醇(E2)、卵泡刺激素(FSH)水平的影响。方法选取 130例 2018年 1—8月在张家港市中医医院接受治疗的真菌性阴道炎病人，按照随机数字表法分为对照组(65例)和观察组(65例)。对照组给予克霉唑阴道片治疗，观察组给予克霉唑阴道片与替勃龙治疗，疗程 1个月。观察并记录病人治疗前后血清 FSH、E2水平，症状消失时间以及疗效。结果对照组治疗前、治疗 14 d、治疗 30 d后 FSH分别为(79.8±15.6)、(56.3±13.25)、(41.35±11.62)IU/L，观察组治疗前、治疗 14 d、治疗 30 d后 FSH分别为(79.7±15.2)、(53.6±13.23)、(35.75±11.63)IU/L。随着治疗的进行两组病人 FSH水平呈降低趋势(F＝10.643、7.612、9.236，P＝0.000、0.012、0.003)，但观察组病人降低程度显著高于对照组(P＜0.05)。对照组治疗前、治疗 14 d、治疗 30 d E2分别为(10.43±1.83)、(15.35±1.72)、(17.43±1.77) pmol/L，观察组治疗前、治疗 14 d、治疗 30 d E2分别为(10.82±1.82)、(18.24±1.76)、(21.34±1.75)pmol/L。经重复方差分析，治疗后两组病人 E2水平呈升高趋势(F＝11.849、8.482、9.227，P＝0.000、0.010、0.001)观察组病人升高程度显著高于对照组(P＜0.05)；观察组外阴瘙痒消失、阴道黏膜充血消失、分泌物消失时间均明显少于对(P＜0.05)；经秩和检验，观察组病人总有效率显著高于对照组(93.85%比 76.92%，P＜0.05)。结论克霉唑阴道片与替勃龙能有效调整真菌性阴道炎病人血清 FSH、 照组，E2水平，改善病人治疗效果，值得在临床广泛推广。 |
| 英文摘要: |
| Objective To explore and analyze the effect of combined application of clotrimazole vaginal tablets and tibolone inthe treatment of mycotic vaginitis and the influence on serum E2(estradiol)and FSH(follicle stimulating hormone)levels.Meth? ods A total of 130 patients with mycotic vaginitis treated in Zhangjiagang Hospital of Traditional Chinese Medicine from Januaryto August in 2018 were randomly divided into control group(65 cases)and observation group(65 cases).The control group was treated with clotrimazole vaginal tablets，and the observation group was treated with clotrimazole vaginal tablets and tibolone for 1 month.The serum FSH and E2 levels，symptom disappearance time and curative effect were observed and recorded before and after treatment.Results FSH level before treatment，14 days and 30 days after treatment was(79.8±15.6)，(56.3±13.25)and(41.35±11.62)IU/L in the control group，and(79.7±15.2)，(53.6±13.23)and(35.75±11.63)IU/L in the observation group.After repeated analysis of variance，there were significant differences in FSH between the two groups before and after treatment(F＝10.643， 7.612，9.236，P＝0.000，0.012，0.003).With the progress of treatment，the level of FSH in the two groups showed a decreasing trend，but the decreasing degree of patients in the observation group was significantly higher than that in the control group(P＜0.05)； the E2 levels before treatment，14 days of treatment and 30 days of treatment of the control group were［10.43±1.83，(15.35± |
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