| 金凤,顾向阳,霍俊.丙酸氟替卡松鼻喷雾剂对变应性鼻炎疗效及白细胞介素?2、白细胞介素?6、降钙素原水平的影响[J].安徽医药,2021,25(1):173-175. |
| 丙酸氟替卡松鼻喷雾剂对变应性鼻炎疗效及白细胞介素?2、白细胞介素?6、降钙素原水平的影响 |
| Efficacy and influence of levels of IL?2, IL?6 and PCT of fluticasone propionate nasal spray in the treatment of patients with allergic rhinitis |
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| DOI：10.3969/j.issn.1009?6469.2021.01.043. |
| 中文关键词: 鼻炎，变应性，常年性 氟替卡松 鼻用喷雾剂 治疗结果 白细胞介素 2 降钙素原 |
| 英文关键词: Rhinitis,allergic,perennial Fluticasone Nasal sprays Treatment outcome Interleukin?2 Calcitonin original |
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| 中文摘要: |
| 目的观察丙酸氟替卡松鼻喷雾剂对变应性鼻炎病人的疗效及白细胞介素 ?2(IL?2)、白细胞介素 ?6(IL?6)、降钙素原(PCT)水平的影响。方法以 2016年 2月至 2019年 2月上海市徐汇区中心医院收治的 90例变应性鼻炎病人为研究对象，将其以随机抽签法等分成试验组与对照组。对照组予以氯雷他定(开瑞坦)治疗，试验组则予以丙酸氟替卡松鼻喷雾剂(辅舒良)鼻喷雾剂治疗。比较两组在临床疗效，治疗前后症状积分，治疗前后血清 IL?2、IL?6、PCT水平，不良反应发生情况。结果试验组治疗总有效率为 97.78%(44/45)，相比对照组 84.44%(38/45)高(P＜0.05)。治疗后试验组与对照组症状积分相比治疗前较低，且试验组比对照组低(均 P＜0.05)。治疗后试验组血清 IL?2、IL?6、PCT水平均低于对照组(均 P＜0.05)。两组在头晕、恶心、嗜睡发生率方面差异无统计学意义(均 P＞0.05)。结论丙酸氟替卡松鼻喷雾剂应用于变应性鼻炎疗效显著，可显著下调血清IL?2、IL?6、PCT水平，安全性较好，值得临床推广应用。 |
| 英文摘要: |
| Objective To study the efficacy of Fushuliang nasal spray on patients with allergic rhinitis and to analyze the effects of interleukin?2(IL?2)interleukin?6(IL?6)，and procalcitonin(PCT)levels.Methods A total of 90 patients with allergic rhinitistreatedinourhospitalfro，m February 2016 to February 2019 wereselected as the research subjects，and randomly divided into the experimental group and the control group.The control group was treated with loratadine(karetan)，while the experimental group was treated with fluticasone propionate(shuliang nasa)l spray.The differences in clinical efficacy，symptom score before and after treat? ment，serum IL?2，IL?6，PCT level before and after treatment，and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 97.78%(44/45)，which was higher than 84.44%(38/45)in the control group(P＜0.05).After treatment，the symptom score of the experimental group was lower than the control group before treatment(all P＜0.05).The serum IL?2，IL?6 and PCT levels of the experimental group were all lower than the control group after treatment(all P＜0.05).The incidence rate of dizziness，nausea and lethargy was not significant between the ex? perimental group and the control group(all P＞0.05).Conclusion Fluticasone propionate(Fushuliang)nasal spray can signifi? cantly improve the clinical symptoms of allergic rhinitis，significantly down?regulate the levels of serum IL?2，IL?6 and PCT.It has good safety is safe and worthy of clinical application. |
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