| 左靖,王龙,孟珺.吉伯特综合征的诊疗与药学监护[J].安徽医药,2021,25(1):194-197. |
| 吉伯特综合征的诊疗与药学监护 |
| Diagnosis，treatment and pharmaceutical care of Gilbert syndrome |
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| DOI：10.3969/j.issn.1009?6469.2021.01.049. |
| 中文关键词: 药学服务 吉尔伯特病 葡糖醛酸基转移酶 基因突变 |
| 英文关键词: Pharmaceutical services Gilbert disease Glucuronosyltransferase Gene mutation |
| 基金项目:深圳市科技计划项目(JCYJ20170307112807219) |
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| 中文摘要: |
| 目的分析吉伯特综合征的诊疗过程与药学监护重点，为药师参与临床合理用药提供参考依据。方法分析 1例吉伯特综合征病人的诊疗过程及药学监护过程，指出吉伯特综合征的诊疗标准以及尿苷二磷酸葡萄糖醛酸转移酶(UGT)1A1基因多态性对药物的代谢的影响，讨论临床药师在该诊疗过程中的价值。结果吉伯特综合征发病机制与 UGT1A1基因突变相关，检测 UGT1A1突变基因是吉伯特综合征诊断的金标准，药师应以基因检测方法为依托，参与到病人的诊断、治疗以及出院随访的全过程，体现药师在促进合理用药，避免药物的滥用方面的价值。结论药师在帮助吉伯特综合征病人确诊及对病人进行药学监护的过程中，促进了合理用药。 |
| 英文摘要: |
| Objective Analyzing the diagnosis and treatment of Gilbert syndrome and the key points of pharmaceutical care soas to provide references for pharmacists to participate in rational drug use in clinical practice.Methods This study analyzed the diagnosis，treatment and pharmaceutical care of a patient with Gilbert’s syndrome，and pointed out the diagnosis and treatment stan?dards of Gilbert syndrome and the influence of uridine diphosphate glucurono syltransferase(UGT)1A1 gene polymorphism on the metabolism of related drugs，and discussed the value of clinical pharmacists in the diagnosis and treatment process.Results The pathogenesis of Gilbert syndrome is related to mutation of UGT1A1 gene.The detection of UGT1A1 mutation genes is the gold stan?dard for the diagnosis of Gilbert syndrome.The clinical pharmacist should participate in the whole process of diagnosis，treatment， and discharge follow?up of this patient，based on genetic testing methods.This case reflected the value of clinical pharmacists in pro? moting rational drug use，and avoiding drug abuse.Conclusion The clinical pharmacists have promoted rational use of drugs in helping patients with Gilbert’s syndrome to be diagnosed and monitored pharmacologically. |
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