| 荆莉,朱庆贵.某医院内分泌科药品不良反应报告 96例分析[J].安徽医药,2021,25(1):209-212. |
| 某医院内分泌科药品不良反应报告 96例分析 |
| Analysis of 96 cases ofadverse drug reactions reported in endocrinology department of a hospital |
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| DOI：10.3969/j.issn.1009?6469.2021.01.053. |
| 中文关键词: 药物相关性副作用和不良反应 内分泌科 处方不当 药学服务 合理用药 |
| 英文关键词: Drug?related side effects and adverse reactions Endocrinology Inappropriate prescribing Pharmaceutical services The rational use of drugs |
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| 中文摘要: |
| 目的分析内分泌科药品不良反应报告，了解药品不良反应发生特点，为促进临床合理用药提供参考。方法选取南京医科大学附属南京医院内分泌科 2014年 1月至 2018年 12月上报的(除外低血糖反应) 96例药品不良反应(ADR)病例，分析 ADR发生的性别分布、年龄分布、药品种类、药品剂型、给药途径、不良反应严重程度、累计系统及临床表现。结果 96例 ADR报告中，病人男女比例相当， 60岁及以上病人 ADR发生率高(60.42%)；发生 ADR药品种类前三位依次为降糖药(45.83%)、抗菌药物(16.67%)、造影剂(9.38%)； ADR的药占比排名前三位的药物分别是二甲双胍(23.96%)、利拉鲁肽(8.33%)、莫西沙星(8.33%)；发生 ADR的药品剂型主要为注射剂(55.21%)、片剂(39.58%)给药途径主要为口服(44.79%)、静脉滴注(29.17%)及皮下注射(16.67%)；发生 ADR的严重程度分级主要为一般反应(93.75%)，主要累及系统为消化系统(39.58%)、皮肤及其附件，(36.46%)主要临床表现为恶心、呕吐、腹泻、皮疹及皮肤瘙痒。结论内分泌科药物不良反应的特点是老年人发生较多，降糖药及抗物导致的 ADR例数最多， ADR较常累计消化系统、皮肤及其附件的损害。积极开展药学服务，能促进内分泌科菌药，安全合理用药。 |
| 英文摘要: |
| Objective The adverse drug reactions(ADR)report in endocrinology department of hospital were analyzed to under?stand the characteristics of ADR and provide reference for promoting rational drug use in clinic.Methods A total of 96 ADR cas? es(excluding hypoglycemia reactions)reported in the department of endocrinology of Nanjing First Hospital from January 2014 toDecember 2018 were selected to analyze the gender distribution，age distribution，drug types，drug dosage forms，route of administra? tion，severity of adverse reactions，cumulative system and clinical manifestations of ADR.Results Among the 96 cases of ADR re? ports，the proportion of male and female patients was equal，and the incidence of ADR in patients aged 60 years or above was high(60.42%)； The top three types of ADR drugs were hypoglycemic drugs(45.83%)， antibacterial agents(16.67%) and contrast agents(9.38%)； The top three drugs in the proportion of ADR were metformin(23.96%)，lillarutide(8.33%)and moxifloxacin(8.33%)； The drug dosage forms of ADR were mainly injection(55.21%) and tablet(39.58%)， with oral administration(44.79%)intravenous infusion(29.17%)and subcutaneous injection(16.67%).The severity of ADR was mainly classified as gen? eral reaction(，93.75%)，mainly involving the digestive system(39.58%)，the skin and its appendages(36.46%)，and the main clin? ical manifestations were nausea，vomiting，diarrhea，rash and pruritus.Conclusions The ADR in the department of endocrinology of hospital are characterized by that the elderly are more likely to have ADR，and the ADR caused by hypoglycemic agents and an? tibacterial agents is the most frequent，and the ADR often accumulates damage to the digestive system，skin and its accessories.Ac?tive pharmaceutical care can promote safe and rational drug use in endocrinology department. |
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