| 王丽娜,赵瑞婧,高颖,等.阿帕替尼联合多西他赛治疗一线治疗失败非小细胞肺癌疗效的 Meta分析[J].安徽医药,2021,25(4):637-640. |
| 阿帕替尼联合多西他赛治疗一线治疗失败非小细胞肺癌疗效的 Meta分析 |
| A meta-analysis of the efficacy of apatinib combined with docetaxel for first-line failed non-small cell lung cancer |
| |
| DOI：10.3969/j.issn.1009-6469.2021.04.001 |
| 中文关键词: 癌，非小细胞肺 阿帕替尼 多西他赛 抗肿瘤联合化疗方案 Meta分析 |
| 英文关键词: Carcinoma, non-small-cell lung Apatinib Docetaxel Antineoplastic combined chemotherapy protocols Metaanalysis |
| 基金项目:陕西省重点研发计划项目(2019SF-020)；陕西省中医管理局中医药科研课题(JCMS062)；西安市科技计划项目［201805093YX1SF27(1)］ |
|
| 摘要点击次数: 1740 |
| 全文下载次数: 531 |
| 中文摘要: |
| 目的用 Meta分析评价阿帕替尼联合多西他赛治疗一线治疗失败的非小细胞肺癌的疗效。方法检索 PubMed、 FMRS、CNKI、和万方医学网等数据库，检索时间截至 2020年 3月，纳入的临床随机对照试验是指研究阿帕替尼联合多西他赛对一线治疗失败的非小细胞肺癌的疗效。被检索文献经筛选后提取资料、 Cochrane系统评价方法学质量评价，进而采用 Rev Man 5.3.0软件进行 Meta分析。结果共纳入 7个临床试验研究，合计 765例。阿帕替尼联合多西他赛针在治疗一线治疗失败的非小细胞肺癌具有更高的疾病控制率，与阿帕替尼单药相比，差异有统计学意义(OR=4.55，P<0.0001，95%CI=3.25~6.38)；药过程中虽仍会出现与药物相关的不良反应，但两组相比较，高血压(OR=0.75，P=0.77，95%CI:0.11~5.04)、蛋白尿(OR=1.10，P用=0.91，95%CI:0.21~5.78)和手足综合征(OR=1.90，P=0.15，95%CI:0.80~4.52)发生率差异无统计学意义，惟胃肠道反应(OR=2.34，P<0.001，95%CI:1.44~3.81)的发生率联合用药组高于单药治疗组，差异有统计学意义。结论在一线治疗失败的非小细胞肺癌的治疗中，阿帕替尼联合多西他赛取得显著疗效，临床值得推广。 |
| 英文摘要: |
| Objective To evaluate the efficacy of apatinib combined with docetaxel in the treatment of non-small cell lung cancer that has failed first-line treatment.Methods Databases such as PubMed, FMRS, CNKI and wanfang medical network were searched byMarch 2020. The included randomized controlled clinical trials refer to the efficacy study of apatinib combined with docetaxel in non-small cell lung cancer patients with first-line treatment failure. The retrieved literature was screened and extracted, the Cochrane systematic review methodology was evaluated for quality, and then the Rev Man5.3.0 software was used for Meta-analysis.Results A total of 7 clinical trials were included, with a total of 765 patients. Apatinib combined with docetaxel had a higher disease control rate in the first-line treatment of non-small cell lung cancer, compared with apatinib alone, the difference was statistically significant (OR=4.55,P< 0.0001,95%CI=3.25-6.38); although there were still drug-related adverse reactions in the process of medication, the incidence of adverse reactions in the two groups with hypertension (OR=0.75, P=0.77, 95%CI: 0.11-5.04) and proteinuria (OR=1.10, P=0.91, 95%CI: 0.21-5.78) and hand-foot syndrome (OR=1.90, P=0.15, 95%CI: 0.80-4.52) was no statistically significant difference.Gastrointestinal reactions (OR=2.34, P<0.001, 95%CI:1.44-3.81) were higher than those of the control group, the latter was statistically significant.Conclu? sion Apatinib combined with docetaxel has achieved significant results in the treatment of non-small cell lung cancer patients with first-line treatment failure, and it is clinically worthy of promotion. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
