| 张帆,邸泰霖,韩克松.免疫球蛋白水平对术后结直肠癌复发的影响及预测价值分析[J].安徽医药,2021,25(4):726-729. |
| 免疫球蛋白水平对术后结直肠癌复发的影响及预测价值分析 |
| The level of immunoglobulin influenced recurrence of colorectal carcinoma after laparoscopic resection |
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| DOI：10.3969/j.issn.1009-6469.2021.04.022 |
| 中文关键词: 结直肠肿瘤 免疫球蛋白 复发 影响因素 预测 |
| 英文关键词: Colorectal neoplasms Immunoglobulin Recurrent Risk factors Prediction |
| 基金项目:廊坊市科技支撑计划项目(2018013153) |
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| 中文摘要: |
| 目的探讨免疫球蛋白的水平对经腹腔镜根治术后的结直肠癌临床结局的影响，并分析其预测结直肠癌复发的价值。方法纳入 2015年 1月至 2016年 1月在河北中石油中心医院行腹腔镜根治术治疗的原发结直肠癌 120例进行随访。采集病人术后第一天外周血并检测免疫球蛋白 G(IgG)、免疫球蛋白 A(IgA)、免疫球蛋白 M(IgM)的含量，采用两独立样本 t检验分析其术后复发和未复发病人间差异；利用 logistic回归模型判断各指标与复发的关联；最后采用 ROC曲线分析其在预测结直肠癌术后复发的价值。结果术后复发组 IgG(17.36±1.99)g/L、IgM(2.03±0.83)g/L和 IgA(3.86±0.63)g/L的水平显著高于未复发组 |
| 英文摘要: |
| Objective To investigate the influences of the levels of immunoglobulin in peripheral blood of patients with colorectalcarcinoma after laparoscopic resection on clinical outcomes, and to analyze their predictive value for postoperative recurrence.Meth? ods The clinical data were collected from through follow-up 120 patients with colorectal carcinoma who underwent laparoscopic resection in Hebei Petro China Central Hospital from January 2015 to January 2016. Detecting the levels of IgG, IgM and IgA after Peripheral blood were obtained from 120 patients on the first day postoperatively, and the different of patients with recurrence and without recurrence after the operation were compared with independent t-test, and the correlation between each index and recurrence was analyzedwith logistic regression. Finally, ROC curve was used to analyze its value in predicting postoperative recurrence of colorectal carcinoma.Results We found that levels of IgG(17.36±1.99) g/L, IgM(2.03±0.83)g/L and IgA(3.86±0.63)g/L in recrudesce patients were higher in non-recrudesce patients (15.31±2.02)g/L,(1.58±0.65) g/L, (3.15±0.71)g/L (P<0.05), and logistic regression analysis found that the IgG, IgM and IgA were independent risk factors [all OR>1, the OR value were 2.11(1.33-3.27), 3.83 (1.44-8.01), and 5.67 (2.19-9.72),respectively]. ROC curve analysis showed that levels of IgG, IgM and IgA had certain predictive value for predicting postoperative recurrence, the OR value were 0.761 (0.657,0.865), 0.666 (0.530-0.803), 0.768 (0.677-0.860) and 0.907 (0.842-0.972). At the optimumcut off point of 15.399 g/L, the sensitivity and specificity of the IgG were 0.833 and 0.683, respectively. At the optimum cut off point of 2.035 g/L, the sensitivity and specificity of the IgM were 0.642 and 0.733, respectively. At the optimum cut off point of 3.162 g/L, thesensitivity and specificity of the IgA were 0.895 and 0.710, respectively. The sensitivity of the combination of three markers was 0.917,with a specificity of 0.781.Conclusion Levels of IgG, IgM and IgA are associated with recurrence, and independent prognostic influencing factors for postoperative patients with colorectal carcinoma, its has a certain value in predicting postoperative recurrence of patients. |
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