| 钟丽梅,钟俊炎,杨海媚,等.促红细胞生成素结合蛋白琥珀酸铁用于高危早产儿贫血 150例防治效果分析[J].安徽医药,2021,25(7):1464-1466. |
| 促红细胞生成素结合蛋白琥珀酸铁用于高危早产儿贫血 150例防治效果分析 |
| Analysis of clinical effect of erythropoietin binding protein succinate iron for the prevention and treatment of anemia in high-risk premature infants of 150 cases |
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| DOI：10.3969/j.issn.1009-6469.2021.07.046 |
| 中文关键词: 贫血 婴儿，早产，疾病 促红细胞生成素 蛋白琥珀酸铁 临床效果 |
| 英文关键词: Anemia Infant, premature, diseases Erythropoietin Ferric succinate protein Clinical effect |
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| 中文摘要: |
| 目的分析促红细胞生成素结合蛋白琥珀酸铁用于高危早产儿贫血防治的临床效果。方法选取 2014年 10月至 2017年 10月在深圳市妇幼保健院进行治疗的高危贫血早产儿 300例，采用随机数字表法将病儿分为观察组( 150例)、对照组(150例)。对照组病儿采用促红细胞生成素进行治疗，观察组病儿采用促红细胞生成素结合蛋白琥珀酸铁进行治疗。观察两组病儿实验室指标(铁、铁蛋白、血红蛋白、红细胞计数)体质量，输血情况(输血率、输血次数)，不良反应情况，并进行比较。结果观察组治疗后铁［(25.28±10.25)mmol/L比( 15.53±8.4，9)mmol/L］、铁蛋白［(78.59±17.94)μg/L比( 16.38±7.69)μg/L］、血红蛋白［( 127.05±22.17)g/L vs(111.07±16.95)g/L］、红细胞计数水平［( 4.28±0.23)×1012/L比( 3.39±0.18)×1012/L］显著高于对照组(P<0.05)，观察组治疗后体质量［( 2496.05±178.17)g比( 2270.52±174.04)g］显著高于对照组( P<0.05)，观察组病儿输血率(6.67% vs 26.00%)低于对照组( P<0.05)，输血次数［(1.33±0.24)次比( 2.40±0.14)次］低于对照组( P<0.05)。结论促红细胞生成素结合蛋白琥珀酸铁在治疗高危早产儿贫血的过程中，疗效更确切，可明显改善病儿低铁状态，提高机体造血能力，增加病儿体质量，减少贫血风险，且安全性较好，该方法有助于病儿临床恢复，具有较高的临床价值，值得应用推广。 |
| 英文摘要: |
| Objective To analyze the clinical effect of erythropoietin binding protein succinate iron in the prevention and treatment of anemia in high-risk premature infants.Methods Three hundred premature infants with high-risk anemia treated in Shenzhen maternal and Child Health Hospital from October 2014 to October 2017 were selected and assigned into observation group (150 cases) andcontrol group (150 cases) by random number table method. In the control group, erythropoietin was used for treatment, while in the observation group, erythropoietin binding protein ferric succinate was used for treatment. The laboratory indexes (iron, SF, Hb, RBC), bodymass, blood transfusion status (blood transfusion rate, blood transfusion times) and adverse reactions were observed in the two groups,and the results were compared.Results Iron [(25.28±10.25) mmol/L vs. (15.53±8.49) mmol/L], SF [(78.59±17.94) μg/L vs. (16.38± 7.69) μg/L], Hb [(127.05±22.17) g/L vs. (111.07±16.95) g/L] and RBC [(4.28±0.23)×1012/L vs. (3.39±0.18)×1012/L] levels in the observation group were significantly higher than those in the control group (P<0.05). The postoperative body quality [(2496.05±178.17) g vs. (2270.52±174.04) g] of the observation group was significantly higher than that of the control group (P<0.05). The transfusion rateof the observation group was lower than that of the control group (6.67% vs. 26.00%, P<0.05), and the number of blood transfusion [(1.33±0.24) times vs. (2.40±0.14) times] was lower than that of the control group (P<0.05).Conclusion Erythropoietin binding protein succinic acid in the process of the iron in the treatment of high-risk premature anemia, curative effect is more accurate. It can significantly improve thechildren with low iron status, improve the ability of hematopoiesis, increase with the weight, and reduce the risk of anemia, with bettersafety. This method can help children with clinical recovery, has high clinical value, is worth popularizing application. |
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